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Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery

Barrier membranes are commonly used as part of the dental surgical technique guided bone regeneration (GBR) and are often made of resorbable collagen or non-resorbable materials such as PTFE. While collagen membranes do not provide sufficient mechanical protection of the covered bone defect, titaniu...

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Autores principales: Rider, Patrick, Kačarević, Željka Perić, Elad, Akiva, Tadic, Drazen, Rothamel, Daniel, Sauer, Gerrit, Bornert, Fabien, Windisch, Peter, Hangyási, Dávid Botond, Molnar, Balint, Bortel, Emely, Hesse, Bernhard, Witte, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892166/
https://www.ncbi.nlm.nih.gov/pubmed/35310351
http://dx.doi.org/10.1016/j.bioactmat.2021.11.018
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author Rider, Patrick
Kačarević, Željka Perić
Elad, Akiva
Tadic, Drazen
Rothamel, Daniel
Sauer, Gerrit
Bornert, Fabien
Windisch, Peter
Hangyási, Dávid Botond
Molnar, Balint
Bortel, Emely
Hesse, Bernhard
Witte, Frank
author_facet Rider, Patrick
Kačarević, Željka Perić
Elad, Akiva
Tadic, Drazen
Rothamel, Daniel
Sauer, Gerrit
Bornert, Fabien
Windisch, Peter
Hangyási, Dávid Botond
Molnar, Balint
Bortel, Emely
Hesse, Bernhard
Witte, Frank
author_sort Rider, Patrick
collection PubMed
description Barrier membranes are commonly used as part of the dental surgical technique guided bone regeneration (GBR) and are often made of resorbable collagen or non-resorbable materials such as PTFE. While collagen membranes do not provide sufficient mechanical protection of the covered bone defect, titanium reinforced membranes and non-resorbable membranes need to be removed in a second surgery. Thus, biodegradable GBR membranes made of pure magnesium might be an alternative. In this study a biodegradable pure magnesium (99.95%) membrane has been proven to have all of the necessary requirements for an optimal regenerative outcome from both a mechanical and biological perspective. After implantation, the magnesium membrane separates the regenerating bone from the overlying, faster proliferating soft tissue. During the initial healing period, the membrane maintained a barrier function and space provision, whilst retaining the positioning of the bone graft material within the defect space. As the magnesium metal corroded, it formed a salty corrosion layer and local gas cavities, both of which extended the functional lifespan of the membrane barrier capabilities. During the resorption of the magnesium metal and magnesium salts, it was observed that the membrane became surrounded and then replaced by new bone. After the membrane had completely resorbed, only healthy tissue remained. The in vivo performance study demonstrated that the magnesium membrane has a comparable healing response and tissue regeneration to that of a resorbable collagen membrane. Overall, the magnesium membrane demonstrated all of the ideal qualities for a barrier membrane used in GBR treatment.
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spelling pubmed-88921662022-03-17 Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery Rider, Patrick Kačarević, Željka Perić Elad, Akiva Tadic, Drazen Rothamel, Daniel Sauer, Gerrit Bornert, Fabien Windisch, Peter Hangyási, Dávid Botond Molnar, Balint Bortel, Emely Hesse, Bernhard Witte, Frank Bioact Mater Article Barrier membranes are commonly used as part of the dental surgical technique guided bone regeneration (GBR) and are often made of resorbable collagen or non-resorbable materials such as PTFE. While collagen membranes do not provide sufficient mechanical protection of the covered bone defect, titanium reinforced membranes and non-resorbable membranes need to be removed in a second surgery. Thus, biodegradable GBR membranes made of pure magnesium might be an alternative. In this study a biodegradable pure magnesium (99.95%) membrane has been proven to have all of the necessary requirements for an optimal regenerative outcome from both a mechanical and biological perspective. After implantation, the magnesium membrane separates the regenerating bone from the overlying, faster proliferating soft tissue. During the initial healing period, the membrane maintained a barrier function and space provision, whilst retaining the positioning of the bone graft material within the defect space. As the magnesium metal corroded, it formed a salty corrosion layer and local gas cavities, both of which extended the functional lifespan of the membrane barrier capabilities. During the resorption of the magnesium metal and magnesium salts, it was observed that the membrane became surrounded and then replaced by new bone. After the membrane had completely resorbed, only healthy tissue remained. The in vivo performance study demonstrated that the magnesium membrane has a comparable healing response and tissue regeneration to that of a resorbable collagen membrane. Overall, the magnesium membrane demonstrated all of the ideal qualities for a barrier membrane used in GBR treatment. KeAi Publishing 2021-11-29 /pmc/articles/PMC8892166/ /pubmed/35310351 http://dx.doi.org/10.1016/j.bioactmat.2021.11.018 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rider, Patrick
Kačarević, Željka Perić
Elad, Akiva
Tadic, Drazen
Rothamel, Daniel
Sauer, Gerrit
Bornert, Fabien
Windisch, Peter
Hangyási, Dávid Botond
Molnar, Balint
Bortel, Emely
Hesse, Bernhard
Witte, Frank
Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery
title Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery
title_full Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery
title_fullStr Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery
title_full_unstemmed Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery
title_short Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery
title_sort biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892166/
https://www.ncbi.nlm.nih.gov/pubmed/35310351
http://dx.doi.org/10.1016/j.bioactmat.2021.11.018
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