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Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery
Barrier membranes are commonly used as part of the dental surgical technique guided bone regeneration (GBR) and are often made of resorbable collagen or non-resorbable materials such as PTFE. While collagen membranes do not provide sufficient mechanical protection of the covered bone defect, titaniu...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892166/ https://www.ncbi.nlm.nih.gov/pubmed/35310351 http://dx.doi.org/10.1016/j.bioactmat.2021.11.018 |
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author | Rider, Patrick Kačarević, Željka Perić Elad, Akiva Tadic, Drazen Rothamel, Daniel Sauer, Gerrit Bornert, Fabien Windisch, Peter Hangyási, Dávid Botond Molnar, Balint Bortel, Emely Hesse, Bernhard Witte, Frank |
author_facet | Rider, Patrick Kačarević, Željka Perić Elad, Akiva Tadic, Drazen Rothamel, Daniel Sauer, Gerrit Bornert, Fabien Windisch, Peter Hangyási, Dávid Botond Molnar, Balint Bortel, Emely Hesse, Bernhard Witte, Frank |
author_sort | Rider, Patrick |
collection | PubMed |
description | Barrier membranes are commonly used as part of the dental surgical technique guided bone regeneration (GBR) and are often made of resorbable collagen or non-resorbable materials such as PTFE. While collagen membranes do not provide sufficient mechanical protection of the covered bone defect, titanium reinforced membranes and non-resorbable membranes need to be removed in a second surgery. Thus, biodegradable GBR membranes made of pure magnesium might be an alternative. In this study a biodegradable pure magnesium (99.95%) membrane has been proven to have all of the necessary requirements for an optimal regenerative outcome from both a mechanical and biological perspective. After implantation, the magnesium membrane separates the regenerating bone from the overlying, faster proliferating soft tissue. During the initial healing period, the membrane maintained a barrier function and space provision, whilst retaining the positioning of the bone graft material within the defect space. As the magnesium metal corroded, it formed a salty corrosion layer and local gas cavities, both of which extended the functional lifespan of the membrane barrier capabilities. During the resorption of the magnesium metal and magnesium salts, it was observed that the membrane became surrounded and then replaced by new bone. After the membrane had completely resorbed, only healthy tissue remained. The in vivo performance study demonstrated that the magnesium membrane has a comparable healing response and tissue regeneration to that of a resorbable collagen membrane. Overall, the magnesium membrane demonstrated all of the ideal qualities for a barrier membrane used in GBR treatment. |
format | Online Article Text |
id | pubmed-8892166 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-88921662022-03-17 Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery Rider, Patrick Kačarević, Željka Perić Elad, Akiva Tadic, Drazen Rothamel, Daniel Sauer, Gerrit Bornert, Fabien Windisch, Peter Hangyási, Dávid Botond Molnar, Balint Bortel, Emely Hesse, Bernhard Witte, Frank Bioact Mater Article Barrier membranes are commonly used as part of the dental surgical technique guided bone regeneration (GBR) and are often made of resorbable collagen or non-resorbable materials such as PTFE. While collagen membranes do not provide sufficient mechanical protection of the covered bone defect, titanium reinforced membranes and non-resorbable membranes need to be removed in a second surgery. Thus, biodegradable GBR membranes made of pure magnesium might be an alternative. In this study a biodegradable pure magnesium (99.95%) membrane has been proven to have all of the necessary requirements for an optimal regenerative outcome from both a mechanical and biological perspective. After implantation, the magnesium membrane separates the regenerating bone from the overlying, faster proliferating soft tissue. During the initial healing period, the membrane maintained a barrier function and space provision, whilst retaining the positioning of the bone graft material within the defect space. As the magnesium metal corroded, it formed a salty corrosion layer and local gas cavities, both of which extended the functional lifespan of the membrane barrier capabilities. During the resorption of the magnesium metal and magnesium salts, it was observed that the membrane became surrounded and then replaced by new bone. After the membrane had completely resorbed, only healthy tissue remained. The in vivo performance study demonstrated that the magnesium membrane has a comparable healing response and tissue regeneration to that of a resorbable collagen membrane. Overall, the magnesium membrane demonstrated all of the ideal qualities for a barrier membrane used in GBR treatment. KeAi Publishing 2021-11-29 /pmc/articles/PMC8892166/ /pubmed/35310351 http://dx.doi.org/10.1016/j.bioactmat.2021.11.018 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rider, Patrick Kačarević, Željka Perić Elad, Akiva Tadic, Drazen Rothamel, Daniel Sauer, Gerrit Bornert, Fabien Windisch, Peter Hangyási, Dávid Botond Molnar, Balint Bortel, Emely Hesse, Bernhard Witte, Frank Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery |
title | Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery |
title_full | Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery |
title_fullStr | Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery |
title_full_unstemmed | Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery |
title_short | Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery |
title_sort | biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892166/ https://www.ncbi.nlm.nih.gov/pubmed/35310351 http://dx.doi.org/10.1016/j.bioactmat.2021.11.018 |
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