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The Applications of Metabolic Glycoengineering

Mammalian cell membranes are decorated by the glycocalyx, which offer versatile means of generating biochemical signals. By manipulating the set of glycans displayed on cell surface, it is vital for gaining insight into the cellular behavior modulation and medical and biotechnological adhibition. Al...

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Detalles Bibliográficos
Autores principales: Ying, Liwei, Xu, Junxi, Han, Dawei, Zhang, Qingguo, Hong, Zhenghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892211/
https://www.ncbi.nlm.nih.gov/pubmed/35252203
http://dx.doi.org/10.3389/fcell.2022.840831
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author Ying, Liwei
Xu, Junxi
Han, Dawei
Zhang, Qingguo
Hong, Zhenghua
author_facet Ying, Liwei
Xu, Junxi
Han, Dawei
Zhang, Qingguo
Hong, Zhenghua
author_sort Ying, Liwei
collection PubMed
description Mammalian cell membranes are decorated by the glycocalyx, which offer versatile means of generating biochemical signals. By manipulating the set of glycans displayed on cell surface, it is vital for gaining insight into the cellular behavior modulation and medical and biotechnological adhibition. Although genetic engineering is proven to be an effective approach for cell surface modification, the technique is only suitable for natural and genetically encoded molecules. To circumvent these limitations, non-genetic approaches are developed for modifying cell surfaces with unnatural but functional groups. Here, we review latest development of metabolic glycoengineering (MGE), which enriches the chemical functions of the cell surface and is becoming an intriguing new tool for regenerative medicine and tissue engineering. Particular emphasis of this review is placed on discussing current applications and perspectives of MGE.
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spelling pubmed-88922112022-03-04 The Applications of Metabolic Glycoengineering Ying, Liwei Xu, Junxi Han, Dawei Zhang, Qingguo Hong, Zhenghua Front Cell Dev Biol Cell and Developmental Biology Mammalian cell membranes are decorated by the glycocalyx, which offer versatile means of generating biochemical signals. By manipulating the set of glycans displayed on cell surface, it is vital for gaining insight into the cellular behavior modulation and medical and biotechnological adhibition. Although genetic engineering is proven to be an effective approach for cell surface modification, the technique is only suitable for natural and genetically encoded molecules. To circumvent these limitations, non-genetic approaches are developed for modifying cell surfaces with unnatural but functional groups. Here, we review latest development of metabolic glycoengineering (MGE), which enriches the chemical functions of the cell surface and is becoming an intriguing new tool for regenerative medicine and tissue engineering. Particular emphasis of this review is placed on discussing current applications and perspectives of MGE. Frontiers Media S.A. 2022-02-17 /pmc/articles/PMC8892211/ /pubmed/35252203 http://dx.doi.org/10.3389/fcell.2022.840831 Text en Copyright © 2022 Ying, Xu, Han, Zhang and Hong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Ying, Liwei
Xu, Junxi
Han, Dawei
Zhang, Qingguo
Hong, Zhenghua
The Applications of Metabolic Glycoengineering
title The Applications of Metabolic Glycoengineering
title_full The Applications of Metabolic Glycoengineering
title_fullStr The Applications of Metabolic Glycoengineering
title_full_unstemmed The Applications of Metabolic Glycoengineering
title_short The Applications of Metabolic Glycoengineering
title_sort applications of metabolic glycoengineering
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892211/
https://www.ncbi.nlm.nih.gov/pubmed/35252203
http://dx.doi.org/10.3389/fcell.2022.840831
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