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An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation
Adhesive hydrogels have been recently proposed as a potential option to seal and treat gastric perforation (GP) which causes high mortality despite advancements in surgical treatments. However, to be effective, the hydrogels must have sufficient tissue adhesiveness, tough mechanical property, tunabl...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892218/ https://www.ncbi.nlm.nih.gov/pubmed/35310345 http://dx.doi.org/10.1016/j.bioactmat.2021.11.038 |
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author | Chen, Jing Caserto, Julia S. Ang, Ida Shariati, Kaavian Webb, James Wang, Bo Wang, Xi Bouklas, Nikolaos Ma, Minglin |
author_facet | Chen, Jing Caserto, Julia S. Ang, Ida Shariati, Kaavian Webb, James Wang, Bo Wang, Xi Bouklas, Nikolaos Ma, Minglin |
author_sort | Chen, Jing |
collection | PubMed |
description | Adhesive hydrogels have been recently proposed as a potential option to seal and treat gastric perforation (GP) which causes high mortality despite advancements in surgical treatments. However, to be effective, the hydrogels must have sufficient tissue adhesiveness, tough mechanical property, tunable biodegradability and ideally are easy to apply and form. Herein, we report an adhesive and resilient hydrogel for the sealing and treatment of gastric perforation. The hydrogel consists of a bioactive, transglutaminase (TG)-crosslinked gelatin network and a dynamic, borate-crosslinked poly-N-[Tris(hydroxymethyl)methyl]acrylamide (PTH) network. The hydrogel can be formed in situ, facilitating easy delivery to the GP and allowing for precise sealing of the defects. In vivo experiments, using a perforated stomach mouse model, shows that the adhesive hydrogel plug effectively seals GP defects and promotes gastric mucosa regeneration. Overall, this hydrogel represents a promising biomaterial for GP treatment. |
format | Online Article Text |
id | pubmed-8892218 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-88922182022-03-17 An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation Chen, Jing Caserto, Julia S. Ang, Ida Shariati, Kaavian Webb, James Wang, Bo Wang, Xi Bouklas, Nikolaos Ma, Minglin Bioact Mater Article Adhesive hydrogels have been recently proposed as a potential option to seal and treat gastric perforation (GP) which causes high mortality despite advancements in surgical treatments. However, to be effective, the hydrogels must have sufficient tissue adhesiveness, tough mechanical property, tunable biodegradability and ideally are easy to apply and form. Herein, we report an adhesive and resilient hydrogel for the sealing and treatment of gastric perforation. The hydrogel consists of a bioactive, transglutaminase (TG)-crosslinked gelatin network and a dynamic, borate-crosslinked poly-N-[Tris(hydroxymethyl)methyl]acrylamide (PTH) network. The hydrogel can be formed in situ, facilitating easy delivery to the GP and allowing for precise sealing of the defects. In vivo experiments, using a perforated stomach mouse model, shows that the adhesive hydrogel plug effectively seals GP defects and promotes gastric mucosa regeneration. Overall, this hydrogel represents a promising biomaterial for GP treatment. KeAi Publishing 2021-12-17 /pmc/articles/PMC8892218/ /pubmed/35310345 http://dx.doi.org/10.1016/j.bioactmat.2021.11.038 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Chen, Jing Caserto, Julia S. Ang, Ida Shariati, Kaavian Webb, James Wang, Bo Wang, Xi Bouklas, Nikolaos Ma, Minglin An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation |
title | An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation |
title_full | An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation |
title_fullStr | An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation |
title_full_unstemmed | An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation |
title_short | An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation |
title_sort | adhesive and resilient hydrogel for the sealing and treatment of gastric perforation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892218/ https://www.ncbi.nlm.nih.gov/pubmed/35310345 http://dx.doi.org/10.1016/j.bioactmat.2021.11.038 |
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