An RDH‐Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase

The size of lipid droplets varies greatly in vivo and is determined by both intrinsic and extrinsic factors. From an RNAi screen in Drosophila, we found that knocking down subunits of COP9 signalosome (CSN) results in enlarged lipid droplets under high‐fat, but not normal, conditions. We identified...

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Autores principales: Zhao, Xuefan, Wang, Wei, Yao, Yan, Li, Xia, Huang, Xiahe, Wang, Yingchun, Ding, Mei, Huang, Xun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892243/
https://www.ncbi.nlm.nih.gov/pubmed/35132760
http://dx.doi.org/10.15252/embr.202152669
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author Zhao, Xuefan
Wang, Wei
Yao, Yan
Li, Xia
Huang, Xiahe
Wang, Yingchun
Ding, Mei
Huang, Xun
author_facet Zhao, Xuefan
Wang, Wei
Yao, Yan
Li, Xia
Huang, Xiahe
Wang, Yingchun
Ding, Mei
Huang, Xun
author_sort Zhao, Xuefan
collection PubMed
description The size of lipid droplets varies greatly in vivo and is determined by both intrinsic and extrinsic factors. From an RNAi screen in Drosophila, we found that knocking down subunits of COP9 signalosome (CSN) results in enlarged lipid droplets under high‐fat, but not normal, conditions. We identified CG2064, a retinol dehydrogenase (RDH) homolog, as the proteasomal degradation target of CSN in regulating lipid droplet size. RDH/CG2064 interacts with the lipid droplet‐resident protein Plin2 and the RDH/CG2064‐Plin2 axis acts to reduce the overall level and lipid droplet localization of Bmm/ATGL lipase. This axis is important for larval survival under prolonged starvation. Thus, we discovered an RDH‐Plin2 axis modulates lipid droplet size.
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spelling pubmed-88922432022-03-15 An RDH‐Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase Zhao, Xuefan Wang, Wei Yao, Yan Li, Xia Huang, Xiahe Wang, Yingchun Ding, Mei Huang, Xun EMBO Rep Articles The size of lipid droplets varies greatly in vivo and is determined by both intrinsic and extrinsic factors. From an RNAi screen in Drosophila, we found that knocking down subunits of COP9 signalosome (CSN) results in enlarged lipid droplets under high‐fat, but not normal, conditions. We identified CG2064, a retinol dehydrogenase (RDH) homolog, as the proteasomal degradation target of CSN in regulating lipid droplet size. RDH/CG2064 interacts with the lipid droplet‐resident protein Plin2 and the RDH/CG2064‐Plin2 axis acts to reduce the overall level and lipid droplet localization of Bmm/ATGL lipase. This axis is important for larval survival under prolonged starvation. Thus, we discovered an RDH‐Plin2 axis modulates lipid droplet size. John Wiley and Sons Inc. 2022-02-08 2022-03-03 /pmc/articles/PMC8892243/ /pubmed/35132760 http://dx.doi.org/10.15252/embr.202152669 Text en © 2022 The Authors. Published under the terms of the CC BY NC ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Articles
Zhao, Xuefan
Wang, Wei
Yao, Yan
Li, Xia
Huang, Xiahe
Wang, Yingchun
Ding, Mei
Huang, Xun
An RDH‐Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase
title An RDH‐Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase
title_full An RDH‐Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase
title_fullStr An RDH‐Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase
title_full_unstemmed An RDH‐Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase
title_short An RDH‐Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase
title_sort rdh‐plin2 axis modulates lipid droplet size by antagonizing bmm lipase
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892243/
https://www.ncbi.nlm.nih.gov/pubmed/35132760
http://dx.doi.org/10.15252/embr.202152669
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