Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN

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High-fidelity replication of the large RNA genome of coronaviruses (CoVs) is mediated by a 3′-to-5′ exoribonuclease (ExoN) in nonstructural protein 14 (nsp14), which excises nucleotides including antiviral drugs misincorporated by the low-fidelity viral RNA-dependent RNA polymerase (RdRp) and has al...

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Detalles Bibliográficos
Autores principales: Moeller, Nicholas H., Shi, Ke, Demir, Özlem, Belica, Christopher, Banerjee, Surajit, Yin, Lulu, Durfee, Cameron, Amaro, Rommie E., Aihara, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892293/
https://www.ncbi.nlm.nih.gov/pubmed/35165203
http://dx.doi.org/10.1073/pnas.2106379119
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