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The nonredundant nature of the Axin2 regulatory network in the canonical Wnt signaling pathway

Axin is one of two essential scaffolds in the canonical Wnt pathway that converts signals at the plasma membrane to signals inhibiting the degradation of β-catenin, leading to its accumulation and specific gene activation. In vertebrates, there are two forms of Axin, Axin1 and Axin2, which are simil...

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Detalles Bibliográficos
Autores principales: Moshkovsky, Ana R., Kirschner, Marc W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892335/
https://www.ncbi.nlm.nih.gov/pubmed/35197279
http://dx.doi.org/10.1073/pnas.2108408119
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author Moshkovsky, Ana R.
Kirschner, Marc W.
author_facet Moshkovsky, Ana R.
Kirschner, Marc W.
author_sort Moshkovsky, Ana R.
collection PubMed
description Axin is one of two essential scaffolds in the canonical Wnt pathway that converts signals at the plasma membrane to signals inhibiting the degradation of β-catenin, leading to its accumulation and specific gene activation. In vertebrates, there are two forms of Axin, Axin1 and Axin2, which are similar at the protein level and genetically redundant. We show here that differential regulation of the two genes on the transcriptional and proteostatic level confers differential responsiveness that can be used in tissue-specific regulation. Such subtle features may distinguish other redundant gene pairs that are commonly found in vertebrates through gene knockout experiments.
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spelling pubmed-88923352022-08-23 The nonredundant nature of the Axin2 regulatory network in the canonical Wnt signaling pathway Moshkovsky, Ana R. Kirschner, Marc W. Proc Natl Acad Sci U S A Biological Sciences Axin is one of two essential scaffolds in the canonical Wnt pathway that converts signals at the plasma membrane to signals inhibiting the degradation of β-catenin, leading to its accumulation and specific gene activation. In vertebrates, there are two forms of Axin, Axin1 and Axin2, which are similar at the protein level and genetically redundant. We show here that differential regulation of the two genes on the transcriptional and proteostatic level confers differential responsiveness that can be used in tissue-specific regulation. Such subtle features may distinguish other redundant gene pairs that are commonly found in vertebrates through gene knockout experiments. National Academy of Sciences 2022-02-23 2022-03-01 /pmc/articles/PMC8892335/ /pubmed/35197279 http://dx.doi.org/10.1073/pnas.2108408119 Text en Copyright © 2022 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Moshkovsky, Ana R.
Kirschner, Marc W.
The nonredundant nature of the Axin2 regulatory network in the canonical Wnt signaling pathway
title The nonredundant nature of the Axin2 regulatory network in the canonical Wnt signaling pathway
title_full The nonredundant nature of the Axin2 regulatory network in the canonical Wnt signaling pathway
title_fullStr The nonredundant nature of the Axin2 regulatory network in the canonical Wnt signaling pathway
title_full_unstemmed The nonredundant nature of the Axin2 regulatory network in the canonical Wnt signaling pathway
title_short The nonredundant nature of the Axin2 regulatory network in the canonical Wnt signaling pathway
title_sort nonredundant nature of the axin2 regulatory network in the canonical wnt signaling pathway
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892335/
https://www.ncbi.nlm.nih.gov/pubmed/35197279
http://dx.doi.org/10.1073/pnas.2108408119
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