Mitochondrial COA7 is a heme-binding protein with disulfide reductase activity, which acts in the early stages of complex IV assembly

Cytochrome c oxidase (COX) assembly factor 7 (COA7) is a metazoan-specific assembly factor, critical for the biogenesis of mitochondrial complex IV (cytochrome c oxidase). Although mutations in COA7 have been linked to complex IV assembly defects and neurological conditions such as peripheral neurop...

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Detalles Bibliográficos
Autores principales: Formosa, Luke E., Maghool, Shadi, Sharpe, Alice J., Reljic, Boris, Muellner-Wong, Linden, Stroud, David A., Ryan, Michael T., Maher, Megan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892353/
https://www.ncbi.nlm.nih.gov/pubmed/35210360
http://dx.doi.org/10.1073/pnas.2110357119

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