Ratiometric pH-Responsive (19)F Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches

[Image: see text] Hydrazone-based molecular switches serve as efficient ratiometric pH-sensitive agents that can be tracked with (19)F NMR/MRI and (1)H NMR. Structural changes induced between pH 3 and 4 lead to signal appearance and disappearance at (1)H and (19)F NMR spectra allowing ratiometric pH...

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Detalles Bibliográficos
Autores principales: Janasik, Dawid, Jasiński, Krzysztof, Węglarz, Władysław P., Nemec, Ivan, Jewula, Pawel, Krawczyk, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892427/
https://www.ncbi.nlm.nih.gov/pubmed/35156816
http://dx.doi.org/10.1021/acs.analchem.1c04978
Descripción
Sumario:[Image: see text] Hydrazone-based molecular switches serve as efficient ratiometric pH-sensitive agents that can be tracked with (19)F NMR/MRI and (1)H NMR. Structural changes induced between pH 3 and 4 lead to signal appearance and disappearance at (1)H and (19)F NMR spectra allowing ratiometric pH measurements. The most pronounced are resonances of the CF(3) group shifted by 1.8 ppm with (19)F NMR and a hydrazone proton shifted by 2 ppm with (1)H NMR.

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