Ratiometric pH-Responsive (19)F Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches

[Image: see text] Hydrazone-based molecular switches serve as efficient ratiometric pH-sensitive agents that can be tracked with (19)F NMR/MRI and (1)H NMR. Structural changes induced between pH 3 and 4 lead to signal appearance and disappearance at (1)H and (19)F NMR spectra allowing ratiometric pH...

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Autores principales: Janasik, Dawid, Jasiński, Krzysztof, Węglarz, Władysław P., Nemec, Ivan, Jewula, Pawel, Krawczyk, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892427/
https://www.ncbi.nlm.nih.gov/pubmed/35156816
http://dx.doi.org/10.1021/acs.analchem.1c04978
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author Janasik, Dawid
Jasiński, Krzysztof
Węglarz, Władysław P.
Nemec, Ivan
Jewula, Pawel
Krawczyk, Tomasz
author_facet Janasik, Dawid
Jasiński, Krzysztof
Węglarz, Władysław P.
Nemec, Ivan
Jewula, Pawel
Krawczyk, Tomasz
author_sort Janasik, Dawid
collection PubMed
description [Image: see text] Hydrazone-based molecular switches serve as efficient ratiometric pH-sensitive agents that can be tracked with (19)F NMR/MRI and (1)H NMR. Structural changes induced between pH 3 and 4 lead to signal appearance and disappearance at (1)H and (19)F NMR spectra allowing ratiometric pH measurements. The most pronounced are resonances of the CF(3) group shifted by 1.8 ppm with (19)F NMR and a hydrazone proton shifted by 2 ppm with (1)H NMR.
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spelling pubmed-88924272022-03-04 Ratiometric pH-Responsive (19)F Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches Janasik, Dawid Jasiński, Krzysztof Węglarz, Władysław P. Nemec, Ivan Jewula, Pawel Krawczyk, Tomasz Anal Chem [Image: see text] Hydrazone-based molecular switches serve as efficient ratiometric pH-sensitive agents that can be tracked with (19)F NMR/MRI and (1)H NMR. Structural changes induced between pH 3 and 4 lead to signal appearance and disappearance at (1)H and (19)F NMR spectra allowing ratiometric pH measurements. The most pronounced are resonances of the CF(3) group shifted by 1.8 ppm with (19)F NMR and a hydrazone proton shifted by 2 ppm with (1)H NMR. American Chemical Society 2022-02-14 2022-03-01 /pmc/articles/PMC8892427/ /pubmed/35156816 http://dx.doi.org/10.1021/acs.analchem.1c04978 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Janasik, Dawid
Jasiński, Krzysztof
Węglarz, Władysław P.
Nemec, Ivan
Jewula, Pawel
Krawczyk, Tomasz
Ratiometric pH-Responsive (19)F Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches
title Ratiometric pH-Responsive (19)F Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches
title_full Ratiometric pH-Responsive (19)F Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches
title_fullStr Ratiometric pH-Responsive (19)F Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches
title_full_unstemmed Ratiometric pH-Responsive (19)F Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches
title_short Ratiometric pH-Responsive (19)F Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches
title_sort ratiometric ph-responsive (19)f magnetic resonance imaging contrast agents based on hydrazone switches
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892427/
https://www.ncbi.nlm.nih.gov/pubmed/35156816
http://dx.doi.org/10.1021/acs.analchem.1c04978
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