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Association between fatty acid synthase and adipophilin expression in triple-negative breast cancer

It is well known that cancer cells produce energy via anaerobic glycolysis. Lipid metabolism is often upregulated in numerous types of cancer. Our previous study demonstrated that adipophilin (ADP), a lipid-associated protein, was a poor prognostic indicator in patients with triple-negative breast c...

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Autores principales: Yoshikawa, Katsuhiro, Ishida, Mitsuaki, Yanai, Hirotsugu, Tsuta, Koji, Sekimoto, Mitsugu, Sugie, Tomoharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892429/
https://www.ncbi.nlm.nih.gov/pubmed/35251631
http://dx.doi.org/10.3892/mco.2022.2513
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author Yoshikawa, Katsuhiro
Ishida, Mitsuaki
Yanai, Hirotsugu
Tsuta, Koji
Sekimoto, Mitsugu
Sugie, Tomoharu
author_facet Yoshikawa, Katsuhiro
Ishida, Mitsuaki
Yanai, Hirotsugu
Tsuta, Koji
Sekimoto, Mitsugu
Sugie, Tomoharu
author_sort Yoshikawa, Katsuhiro
collection PubMed
description It is well known that cancer cells produce energy via anaerobic glycolysis. Lipid metabolism is often upregulated in numerous types of cancer. Our previous study demonstrated that adipophilin (ADP), a lipid-associated protein, was a poor prognostic indicator in patients with triple-negative breast cancer (TNBC). However, the mechanism of ADP expression in TNBC remains unclear. Fatty acid synthase (FASN) is a crucial enzyme in de novo fatty acid synthesis, and its upregulation has been reported in several types of carcinomas; however, to the best of our knowledge, the association of FASN and ADP in TNBC remains unclear. The present study analysed the association between FASN and ADP expression and the prognostic significance of FASN in TNBC. Using immunohistochemical methods and tissue microarrays, the present study examined FASN expression in 61 patients with TNBC. Overall and relapse-free survival and their risk factors were analysed for FASN expression and compared with ADP expression. A total of 40 (65.6%) patients were classified as FASN-high (score ≥120), and this was significantly associated with a lower Ki-67 labelling index (P=0.011). FASN expression was not associated with relapse-free survival and overall survival. FASN-high was negatively associated with ADP expression (P=0.041). The results of the present study revealed that FASN-high was associated with a lack of ADP expression and a lower Ki-67 labelling index. These results indicated that de novo fatty acid synthesis by FASN is not the main pathway of lipogenesis and the source of energy in cancer cells of ADP-positive highly proliferative TNBC.
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spelling pubmed-88924292022-03-04 Association between fatty acid synthase and adipophilin expression in triple-negative breast cancer Yoshikawa, Katsuhiro Ishida, Mitsuaki Yanai, Hirotsugu Tsuta, Koji Sekimoto, Mitsugu Sugie, Tomoharu Mol Clin Oncol Articles It is well known that cancer cells produce energy via anaerobic glycolysis. Lipid metabolism is often upregulated in numerous types of cancer. Our previous study demonstrated that adipophilin (ADP), a lipid-associated protein, was a poor prognostic indicator in patients with triple-negative breast cancer (TNBC). However, the mechanism of ADP expression in TNBC remains unclear. Fatty acid synthase (FASN) is a crucial enzyme in de novo fatty acid synthesis, and its upregulation has been reported in several types of carcinomas; however, to the best of our knowledge, the association of FASN and ADP in TNBC remains unclear. The present study analysed the association between FASN and ADP expression and the prognostic significance of FASN in TNBC. Using immunohistochemical methods and tissue microarrays, the present study examined FASN expression in 61 patients with TNBC. Overall and relapse-free survival and their risk factors were analysed for FASN expression and compared with ADP expression. A total of 40 (65.6%) patients were classified as FASN-high (score ≥120), and this was significantly associated with a lower Ki-67 labelling index (P=0.011). FASN expression was not associated with relapse-free survival and overall survival. FASN-high was negatively associated with ADP expression (P=0.041). The results of the present study revealed that FASN-high was associated with a lack of ADP expression and a lower Ki-67 labelling index. These results indicated that de novo fatty acid synthesis by FASN is not the main pathway of lipogenesis and the source of energy in cancer cells of ADP-positive highly proliferative TNBC. D.A. Spandidos 2022-04 2022-02-09 /pmc/articles/PMC8892429/ /pubmed/35251631 http://dx.doi.org/10.3892/mco.2022.2513 Text en Copyright: © Yoshikawa et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Yoshikawa, Katsuhiro
Ishida, Mitsuaki
Yanai, Hirotsugu
Tsuta, Koji
Sekimoto, Mitsugu
Sugie, Tomoharu
Association between fatty acid synthase and adipophilin expression in triple-negative breast cancer
title Association between fatty acid synthase and adipophilin expression in triple-negative breast cancer
title_full Association between fatty acid synthase and adipophilin expression in triple-negative breast cancer
title_fullStr Association between fatty acid synthase and adipophilin expression in triple-negative breast cancer
title_full_unstemmed Association between fatty acid synthase and adipophilin expression in triple-negative breast cancer
title_short Association between fatty acid synthase and adipophilin expression in triple-negative breast cancer
title_sort association between fatty acid synthase and adipophilin expression in triple-negative breast cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892429/
https://www.ncbi.nlm.nih.gov/pubmed/35251631
http://dx.doi.org/10.3892/mco.2022.2513
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