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Discovery and Visualization of Uncharacterized Drug–Protein Adducts Using Mass Spectrometry

[Image: see text] Drugs are often metabolized to reactive intermediates that form protein adducts. Adducts can inhibit protein activity, elicit immune responses, and cause life-threatening adverse drug reactions. The masses of reactive metabolites are frequently unknown, rendering traditional mass s...

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Detalles Bibliográficos
Autores principales:	Riffle, Michael, Hoopmann, Michael R., Jaschob, Daniel, Zhong, Guo, Moritz, Robert L., MacCoss, Michael J., Davis, Trisha N., Isoherranen, Nina, Zelter, Alex
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892443/ https://www.ncbi.nlm.nih.gov/pubmed/35184559 http://dx.doi.org/10.1021/acs.analchem.1c04101

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