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Impact of Gleason score of the tumor at the positive surgical margin as a prognostic factor

Although numerous studies have reported that a positive surgical margin (PSM) is the most important predictive factor for biochemical recurrence (BCR) of prostate cancer (PCa), only a small number of studies have evaluated the predictive value of the Gleason score (GS) of the tumor at the margin in...

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Autores principales: Kurose, Hirofumi, Ueda, Kosuke, Ogasawara, Naoyuki, Chikui, Katsuaki, Nakiri, Makoto, Nishihara, Kiyoaki, Matsuo, Mitsunori, Suekane, Shigetaka, Kusano, Hironori, Akiba, Jun, Yano, Hirohisa, Igawa, Tsukasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892462/
https://www.ncbi.nlm.nih.gov/pubmed/35251633
http://dx.doi.org/10.3892/mco.2022.2515
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author Kurose, Hirofumi
Ueda, Kosuke
Ogasawara, Naoyuki
Chikui, Katsuaki
Nakiri, Makoto
Nishihara, Kiyoaki
Matsuo, Mitsunori
Suekane, Shigetaka
Kusano, Hironori
Akiba, Jun
Yano, Hirohisa
Igawa, Tsukasa
author_facet Kurose, Hirofumi
Ueda, Kosuke
Ogasawara, Naoyuki
Chikui, Katsuaki
Nakiri, Makoto
Nishihara, Kiyoaki
Matsuo, Mitsunori
Suekane, Shigetaka
Kusano, Hironori
Akiba, Jun
Yano, Hirohisa
Igawa, Tsukasa
author_sort Kurose, Hirofumi
collection PubMed
description Although numerous studies have reported that a positive surgical margin (PSM) is the most important predictive factor for biochemical recurrence (BCR) of prostate cancer (PCa), only a small number of studies have evaluated the predictive value of the Gleason score (GS) of the tumor at the margin in radical prostatectomy (RP). The present study aimed to investigate the preoperative factors that predict PSM and the significant predictive factors for BCR in cases with PSM. In addition, it was examined whether documenting the GS of the tumor at the margin in pathological reports is useful as a predictive factor for BCR. Data of 241 patients with PCa who underwent RP at Kurume University Hospital (Kurume, Japan) between January 2007 and December 2011 were retrospectively reviewed. The median follow-up period was 72 months and 122 patients had at least one PSM. The time to BCR was significantly shorter in patients with PSM than in those with a negative surgical margin. Multivariate analysis demonstrated that >10 ng/ml prostate-specific antigen at diagnosis (P=0.024) and >25% positive core at biopsy (P=0.041) were independent prognostic preoperative factors for PSM. The GS of the tumor at the margin was equal, lower and higher than those of the main tumor in 74 (60.7%), 16 (13.1%) and 32 (26.2%) RPs, respectively. The BCR rates were 35.7, 55.1 and 82.1% in patients whose GS of the tumor at the margin was 6, 7 and 8-10, respectively (P=0.0017). The GS of the tumor at the PSM (P=0.038) and anatomic location of the PSM (P=0.04) were identified as independent prognostic preoperative factors for BCR, whereas the GS of the main tumor and margin length were not. These results suggest that documenting the GS at the margin in pathological reports is useful as a predictive factor for BCR.
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spelling pubmed-88924622022-03-04 Impact of Gleason score of the tumor at the positive surgical margin as a prognostic factor Kurose, Hirofumi Ueda, Kosuke Ogasawara, Naoyuki Chikui, Katsuaki Nakiri, Makoto Nishihara, Kiyoaki Matsuo, Mitsunori Suekane, Shigetaka Kusano, Hironori Akiba, Jun Yano, Hirohisa Igawa, Tsukasa Mol Clin Oncol Articles Although numerous studies have reported that a positive surgical margin (PSM) is the most important predictive factor for biochemical recurrence (BCR) of prostate cancer (PCa), only a small number of studies have evaluated the predictive value of the Gleason score (GS) of the tumor at the margin in radical prostatectomy (RP). The present study aimed to investigate the preoperative factors that predict PSM and the significant predictive factors for BCR in cases with PSM. In addition, it was examined whether documenting the GS of the tumor at the margin in pathological reports is useful as a predictive factor for BCR. Data of 241 patients with PCa who underwent RP at Kurume University Hospital (Kurume, Japan) between January 2007 and December 2011 were retrospectively reviewed. The median follow-up period was 72 months and 122 patients had at least one PSM. The time to BCR was significantly shorter in patients with PSM than in those with a negative surgical margin. Multivariate analysis demonstrated that >10 ng/ml prostate-specific antigen at diagnosis (P=0.024) and >25% positive core at biopsy (P=0.041) were independent prognostic preoperative factors for PSM. The GS of the tumor at the margin was equal, lower and higher than those of the main tumor in 74 (60.7%), 16 (13.1%) and 32 (26.2%) RPs, respectively. The BCR rates were 35.7, 55.1 and 82.1% in patients whose GS of the tumor at the margin was 6, 7 and 8-10, respectively (P=0.0017). The GS of the tumor at the PSM (P=0.038) and anatomic location of the PSM (P=0.04) were identified as independent prognostic preoperative factors for BCR, whereas the GS of the main tumor and margin length were not. These results suggest that documenting the GS at the margin in pathological reports is useful as a predictive factor for BCR. D.A. Spandidos 2022-04 2022-02-10 /pmc/articles/PMC8892462/ /pubmed/35251633 http://dx.doi.org/10.3892/mco.2022.2515 Text en Copyright: © Kurose et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Kurose, Hirofumi
Ueda, Kosuke
Ogasawara, Naoyuki
Chikui, Katsuaki
Nakiri, Makoto
Nishihara, Kiyoaki
Matsuo, Mitsunori
Suekane, Shigetaka
Kusano, Hironori
Akiba, Jun
Yano, Hirohisa
Igawa, Tsukasa
Impact of Gleason score of the tumor at the positive surgical margin as a prognostic factor
title Impact of Gleason score of the tumor at the positive surgical margin as a prognostic factor
title_full Impact of Gleason score of the tumor at the positive surgical margin as a prognostic factor
title_fullStr Impact of Gleason score of the tumor at the positive surgical margin as a prognostic factor
title_full_unstemmed Impact of Gleason score of the tumor at the positive surgical margin as a prognostic factor
title_short Impact of Gleason score of the tumor at the positive surgical margin as a prognostic factor
title_sort impact of gleason score of the tumor at the positive surgical margin as a prognostic factor
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892462/
https://www.ncbi.nlm.nih.gov/pubmed/35251633
http://dx.doi.org/10.3892/mco.2022.2515
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