A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemia

Acute myeloid leukemias (AMLs) with the NUP98-NSD1 or mixed lineage leukemia (MLL) rearrangement (MLL-r) share transcriptomic profiles associated with stemness-related gene signatures and display poor prognosis. The molecular underpinnings of AML aggressiveness and stemness remain far from clear. St...

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Detalles Bibliográficos
Autores principales: Ren, Zhihong, Kim, Arum, Huang, Yu-Ting, Pi, Wen-Chieh, Gong, Weida, Yu, Xufen, Qi, Jun, Jin, Jian, Cai, Ling, Roeder, Robert G., Chen, Wei-Yi, Wang, Gang Greg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892512/
https://www.ncbi.nlm.nih.gov/pubmed/35217626
http://dx.doi.org/10.1073/pnas.2122940119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892512/
https://www.ncbi.nlm.nih.gov/pubmed/35217626
http://dx.doi.org/10.1073/pnas.2122940119

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