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Case-Fatality Ratio of Enteric Fever: Estimates From Multitiered Surveillance in India
BACKGROUND: The case-fatality ratio (CFR) for enteric fever is essential for estimating disease burden and calibrating measures that balance the likely health gains from interventions against social and economic costs. METHODS: We aimed to estimate the CFR for enteric fever using multiple data sourc...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892535/ https://www.ncbi.nlm.nih.gov/pubmed/35238359 http://dx.doi.org/10.1093/infdis/jiab388 |
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author | Samuel, Prasanna Njarekkattuvalappil, Swathi Krishna Kumar, Dilesh Raju, Reshma Andrews, Jason R Kang, Gagandeep John, Jacob |
author_facet | Samuel, Prasanna Njarekkattuvalappil, Swathi Krishna Kumar, Dilesh Raju, Reshma Andrews, Jason R Kang, Gagandeep John, Jacob |
author_sort | Samuel, Prasanna |
collection | PubMed |
description | BACKGROUND: The case-fatality ratio (CFR) for enteric fever is essential for estimating disease burden and calibrating measures that balance the likely health gains from interventions against social and economic costs. METHODS: We aimed to estimate the CFR for enteric fever using multiple data sources within the National Surveillance System for Enteric Fever in India. This surveillance (2017–2020) was established as a multitiered surveillance system including community cohorts (tier 1), facility-based (tier 2), and tertiary care surveillance (tier 3) for estimating the burden of enteric fever in India. The CFR was calculated after accounting for healthcare-seeking behavior for enteric fever and deaths occurring outside the hospital. RESULTS: A total of 1236 hospitalized patients with blood culture–confirmed enteric fever were enrolled, of which 9 fatal cases were identified, for an estimated hospitalized CFR of 0.73% (95% confidence interval [CI], .33%–1.38%). After adjusting for severity, healthcare-seeking behavior, and deaths occurring out-of-hospital, the CFR was estimated to be 0.16% (95% CI, .07%–.29%) for all enteric fevers. CONCLUSIONS: Our estimates of the CFR are relatively lower than previously estimated, accounting for care-seeking behavior and deaths outside the hospital. |
format | Online Article Text |
id | pubmed-8892535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-88925352022-03-04 Case-Fatality Ratio of Enteric Fever: Estimates From Multitiered Surveillance in India Samuel, Prasanna Njarekkattuvalappil, Swathi Krishna Kumar, Dilesh Raju, Reshma Andrews, Jason R Kang, Gagandeep John, Jacob J Infect Dis Supplement Articles BACKGROUND: The case-fatality ratio (CFR) for enteric fever is essential for estimating disease burden and calibrating measures that balance the likely health gains from interventions against social and economic costs. METHODS: We aimed to estimate the CFR for enteric fever using multiple data sources within the National Surveillance System for Enteric Fever in India. This surveillance (2017–2020) was established as a multitiered surveillance system including community cohorts (tier 1), facility-based (tier 2), and tertiary care surveillance (tier 3) for estimating the burden of enteric fever in India. The CFR was calculated after accounting for healthcare-seeking behavior for enteric fever and deaths occurring outside the hospital. RESULTS: A total of 1236 hospitalized patients with blood culture–confirmed enteric fever were enrolled, of which 9 fatal cases were identified, for an estimated hospitalized CFR of 0.73% (95% confidence interval [CI], .33%–1.38%). After adjusting for severity, healthcare-seeking behavior, and deaths occurring out-of-hospital, the CFR was estimated to be 0.16% (95% CI, .07%–.29%) for all enteric fevers. CONCLUSIONS: Our estimates of the CFR are relatively lower than previously estimated, accounting for care-seeking behavior and deaths outside the hospital. Oxford University Press 2021-11-23 /pmc/articles/PMC8892535/ /pubmed/35238359 http://dx.doi.org/10.1093/infdis/jiab388 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Supplement Articles Samuel, Prasanna Njarekkattuvalappil, Swathi Krishna Kumar, Dilesh Raju, Reshma Andrews, Jason R Kang, Gagandeep John, Jacob Case-Fatality Ratio of Enteric Fever: Estimates From Multitiered Surveillance in India |
title | Case-Fatality Ratio of Enteric Fever: Estimates From Multitiered Surveillance in India |
title_full | Case-Fatality Ratio of Enteric Fever: Estimates From Multitiered Surveillance in India |
title_fullStr | Case-Fatality Ratio of Enteric Fever: Estimates From Multitiered Surveillance in India |
title_full_unstemmed | Case-Fatality Ratio of Enteric Fever: Estimates From Multitiered Surveillance in India |
title_short | Case-Fatality Ratio of Enteric Fever: Estimates From Multitiered Surveillance in India |
title_sort | case-fatality ratio of enteric fever: estimates from multitiered surveillance in india |
topic | Supplement Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892535/ https://www.ncbi.nlm.nih.gov/pubmed/35238359 http://dx.doi.org/10.1093/infdis/jiab388 |
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