ATR inhibitor AZD6738 increases the sensitivity of colorectal cancer cells to 5-fluorouracil by inhibiting repair of DNA damage

The repair of DNA damage caused by chemotherapy in cancer cells occurs mainly at two cell cycle checkpoints (G(1) and G(2)) and is a factor contributing to chemoresistance. Most colorectal cancers harbor mutations in p53, the main pathway involved in the G(1) checkpoint, and thus, are particularly d...

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Detalles Bibliográficos
Autores principales: Suzuki, Takuya, Hirokawa, Takahisa, Maeda, Anri, Harata, Shinnosuke, Watanabe, Kaori, Yanagita, Takeshi, Ushigome, Hajime, Nakai, Nozomi, Maeda, Yuzo, Shiga, Kazuyoshi, Ogawa, Ryo, Mitsui, Akira, Kimura, Masahiro, Matsuo, Yoichi, Takahashi, Hiroki, Takiguchi, Shuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892626/
https://www.ncbi.nlm.nih.gov/pubmed/35191521
http://dx.doi.org/10.3892/or.2022.8289

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