Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions

Over the past decade, the role of proton pump inhibitor (PPI) medication has evolved from a diagnostic tool for Eosinophilic Esophagitis (EoE), by excluding patients with PPI responsive esophageal eosinophilia (PPI-REE), to a therapy for EoE. This transition resulted from the Updated International C...

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Autores principales: Franciosi, James P, Mougey, Edward B, Dellon, Evan S, Gutierrez-Junquera, Carolina, Fernandez-Fernandez, Sonia, Venkatesh, Rajitha D, Gupta, Sandeep K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892718/
https://www.ncbi.nlm.nih.gov/pubmed/35250281
http://dx.doi.org/10.2147/JAA.S274524
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author Franciosi, James P
Mougey, Edward B
Dellon, Evan S
Gutierrez-Junquera, Carolina
Fernandez-Fernandez, Sonia
Venkatesh, Rajitha D
Gupta, Sandeep K
author_facet Franciosi, James P
Mougey, Edward B
Dellon, Evan S
Gutierrez-Junquera, Carolina
Fernandez-Fernandez, Sonia
Venkatesh, Rajitha D
Gupta, Sandeep K
author_sort Franciosi, James P
collection PubMed
description Over the past decade, the role of proton pump inhibitor (PPI) medication has evolved from a diagnostic tool for Eosinophilic Esophagitis (EoE), by excluding patients with PPI responsive esophageal eosinophilia (PPI-REE), to a therapy for EoE. This transition resulted from the Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the Appraisal of Guidelines for Research and Evaluation II (AGREE) Conference to support PPI therapy for EoE in children and adults. Additional recent advances have suggested a role for genetic variations that might impact response to PPI therapy for EoE. This review article will explore a brief background of EoE, the evolution of PPI therapy for EoE and its proposed mechanisms, efficacy and safety in children and adults, and considerations for future PPI precision medicine in patients with EoE.
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spelling pubmed-88927182022-03-04 Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions Franciosi, James P Mougey, Edward B Dellon, Evan S Gutierrez-Junquera, Carolina Fernandez-Fernandez, Sonia Venkatesh, Rajitha D Gupta, Sandeep K J Asthma Allergy Review Over the past decade, the role of proton pump inhibitor (PPI) medication has evolved from a diagnostic tool for Eosinophilic Esophagitis (EoE), by excluding patients with PPI responsive esophageal eosinophilia (PPI-REE), to a therapy for EoE. This transition resulted from the Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the Appraisal of Guidelines for Research and Evaluation II (AGREE) Conference to support PPI therapy for EoE in children and adults. Additional recent advances have suggested a role for genetic variations that might impact response to PPI therapy for EoE. This review article will explore a brief background of EoE, the evolution of PPI therapy for EoE and its proposed mechanisms, efficacy and safety in children and adults, and considerations for future PPI precision medicine in patients with EoE. Dove 2022-02-26 /pmc/articles/PMC8892718/ /pubmed/35250281 http://dx.doi.org/10.2147/JAA.S274524 Text en © 2022 Franciosi et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Franciosi, James P
Mougey, Edward B
Dellon, Evan S
Gutierrez-Junquera, Carolina
Fernandez-Fernandez, Sonia
Venkatesh, Rajitha D
Gupta, Sandeep K
Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions
title Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions
title_full Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions
title_fullStr Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions
title_full_unstemmed Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions
title_short Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions
title_sort proton pump inhibitor therapy for eosinophilic esophagitis: history, mechanisms, efficacy, and future directions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892718/
https://www.ncbi.nlm.nih.gov/pubmed/35250281
http://dx.doi.org/10.2147/JAA.S274524
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