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Evaluating the impact of adjunctive istradefylline on the cumulative dose of levodopa-containing medications in Parkinson’s disease: study protocol for the ISTRA ADJUST PD randomized, controlled study
BACKGROUND: Levodopa remains the most effective symptomatic treatment for Parkinson’s disease (PD) more than 50 years after its clinical introduction. However, the onset of motor complications can limit pharmacological intervention with levodopa, which can be a challenge when treating PD patients. C...
Autores principales: | Hatano, Taku, Kano, Osamu, Sengoku, Renpei, Yoritaka, Asako, Suzuki, Keisuke, Nishikawa, Noriko, Mukai, Yohei, Nomura, Kyoichi, Yoshida, Norihito, Seki, Morinobu, Matsukawa, Miho Kawabe, Terashi, Hiroo, Kimura, Katsuo, Tashiro, Jun, Hirano, Shigeki, Murakami, Hidetomo, Joki, Hideto, Uchiyama, Tsuyoshi, Shimura, Hideki, Ogaki, Kotaro, Fukae, Jiro, Tsuboi, Yoshio, Takahashi, Kazushi, Yamamoto, Toshimasa, Yanagisawa, Naotake, Nagayama, Hiroshi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892732/ https://www.ncbi.nlm.nih.gov/pubmed/35241003 http://dx.doi.org/10.1186/s12883-022-02600-w |
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