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Serum Uric Acid Levels in Relation to Atrial Fibrillation: A Case-Control Study

BACKGROUND: Although serum uric acid (SUA) levels have been reported to be associated with atrial fibrillation (AF), the specific associations remain unclear. The purpose of this study was to investigate the potential relationship of serum uric acid levels to atrial fibrillation. MATERIAL/METHODS: W...

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Autores principales: Zhong, Xia, Jiao, Huachen, Zhao, Dongsheng, Teng, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892768/
https://www.ncbi.nlm.nih.gov/pubmed/35220390
http://dx.doi.org/10.12659/MSM.934007
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author Zhong, Xia
Jiao, Huachen
Zhao, Dongsheng
Teng, Jing
author_facet Zhong, Xia
Jiao, Huachen
Zhao, Dongsheng
Teng, Jing
author_sort Zhong, Xia
collection PubMed
description BACKGROUND: Although serum uric acid (SUA) levels have been reported to be associated with atrial fibrillation (AF), the specific associations remain unclear. The purpose of this study was to investigate the potential relationship of serum uric acid levels to atrial fibrillation. MATERIAL/METHODS: We retrospectively analyzed clinical data of 970 consecutive hospitalized patients (M/F, 519/451; age, 64.78±13.49 years). The study included 478 patients with AF, and 492 age-matched patients with sinus rhythm and no history of arrhythmia as a control group. The t test, ANOVA, chi-squared test, or Fisher exact test were performed to analyze clinical baseline data. RESULTS: Compared with the control group, patients with AF exhibited higher SUA levels (5.66±1.90 vs 5.35±1.55 mg/dL, P=0.006), especially women (P<0.001). Pearson correlation analysis showed SUA was influenced by A/G, PAB, and APOA1 in patients with AF. Logistic regression analysis showed SUA was associated with AF (total: OR=1.002, 95% CI: 1.000–1.003; women: OR=1.005, 95% CI: 1.003–1.007). After adjustment for clinical related factors for AF, SUA was still associated with AF (total: OR=1.004, 95% CI: 1.002–1.006; women: OR=1.005, 95% CI: 1.002–1.009). Also, elevated SUA was positively correlated with A/G and PAB and negatively correlated with APOA1. There were no significant differences in SUA levels in AF subtypes and complications. CONCLUSIONS: Elevated SUA levels were associated with AF, but the independent association was significant only in women. Elevated SUA may promote other AF-related factors and participate in the pathological process of AF.
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spelling pubmed-88927682022-03-24 Serum Uric Acid Levels in Relation to Atrial Fibrillation: A Case-Control Study Zhong, Xia Jiao, Huachen Zhao, Dongsheng Teng, Jing Med Sci Monit Clinical Research BACKGROUND: Although serum uric acid (SUA) levels have been reported to be associated with atrial fibrillation (AF), the specific associations remain unclear. The purpose of this study was to investigate the potential relationship of serum uric acid levels to atrial fibrillation. MATERIAL/METHODS: We retrospectively analyzed clinical data of 970 consecutive hospitalized patients (M/F, 519/451; age, 64.78±13.49 years). The study included 478 patients with AF, and 492 age-matched patients with sinus rhythm and no history of arrhythmia as a control group. The t test, ANOVA, chi-squared test, or Fisher exact test were performed to analyze clinical baseline data. RESULTS: Compared with the control group, patients with AF exhibited higher SUA levels (5.66±1.90 vs 5.35±1.55 mg/dL, P=0.006), especially women (P<0.001). Pearson correlation analysis showed SUA was influenced by A/G, PAB, and APOA1 in patients with AF. Logistic regression analysis showed SUA was associated with AF (total: OR=1.002, 95% CI: 1.000–1.003; women: OR=1.005, 95% CI: 1.003–1.007). After adjustment for clinical related factors for AF, SUA was still associated with AF (total: OR=1.004, 95% CI: 1.002–1.006; women: OR=1.005, 95% CI: 1.002–1.009). Also, elevated SUA was positively correlated with A/G and PAB and negatively correlated with APOA1. There were no significant differences in SUA levels in AF subtypes and complications. CONCLUSIONS: Elevated SUA levels were associated with AF, but the independent association was significant only in women. Elevated SUA may promote other AF-related factors and participate in the pathological process of AF. International Scientific Literature, Inc. 2022-02-27 /pmc/articles/PMC8892768/ /pubmed/35220390 http://dx.doi.org/10.12659/MSM.934007 Text en © Med Sci Monit, 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Clinical Research
Zhong, Xia
Jiao, Huachen
Zhao, Dongsheng
Teng, Jing
Serum Uric Acid Levels in Relation to Atrial Fibrillation: A Case-Control Study
title Serum Uric Acid Levels in Relation to Atrial Fibrillation: A Case-Control Study
title_full Serum Uric Acid Levels in Relation to Atrial Fibrillation: A Case-Control Study
title_fullStr Serum Uric Acid Levels in Relation to Atrial Fibrillation: A Case-Control Study
title_full_unstemmed Serum Uric Acid Levels in Relation to Atrial Fibrillation: A Case-Control Study
title_short Serum Uric Acid Levels in Relation to Atrial Fibrillation: A Case-Control Study
title_sort serum uric acid levels in relation to atrial fibrillation: a case-control study
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892768/
https://www.ncbi.nlm.nih.gov/pubmed/35220390
http://dx.doi.org/10.12659/MSM.934007
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