A roadmap to pulmonary delivery strategies for the treatment of infectious lung diseases

Pulmonary drug delivery is a highly attractive topic for the treatment of infectious lung diseases. Drug delivery via the pulmonary route offers unique advantages of no first-pass effect and high bioavailability, which provides an important means to deliver therapeutics directly to lung lesions. Sta...

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Autores principales: He, Siqin, Gui, Jiajia, Xiong, Kun, Chen, Meiwan, Gao, Huile, Fu, Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892824/
https://www.ncbi.nlm.nih.gov/pubmed/35241085
http://dx.doi.org/10.1186/s12951-022-01307-x
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author He, Siqin
Gui, Jiajia
Xiong, Kun
Chen, Meiwan
Gao, Huile
Fu, Yao
author_facet He, Siqin
Gui, Jiajia
Xiong, Kun
Chen, Meiwan
Gao, Huile
Fu, Yao
author_sort He, Siqin
collection PubMed
description Pulmonary drug delivery is a highly attractive topic for the treatment of infectious lung diseases. Drug delivery via the pulmonary route offers unique advantages of no first-pass effect and high bioavailability, which provides an important means to deliver therapeutics directly to lung lesions. Starting from the structural characteristics of the lungs and the biological barriers for achieving efficient delivery, we aim to review literatures in the past decade regarding the pulmonary delivery strategies used to treat infectious lung diseases. Hopefully, this review article offers new insights into the future development of therapeutic strategies against pulmonary infectious diseases from a delivery point of view. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-88928242022-03-04 A roadmap to pulmonary delivery strategies for the treatment of infectious lung diseases He, Siqin Gui, Jiajia Xiong, Kun Chen, Meiwan Gao, Huile Fu, Yao J Nanobiotechnology Review Pulmonary drug delivery is a highly attractive topic for the treatment of infectious lung diseases. Drug delivery via the pulmonary route offers unique advantages of no first-pass effect and high bioavailability, which provides an important means to deliver therapeutics directly to lung lesions. Starting from the structural characteristics of the lungs and the biological barriers for achieving efficient delivery, we aim to review literatures in the past decade regarding the pulmonary delivery strategies used to treat infectious lung diseases. Hopefully, this review article offers new insights into the future development of therapeutic strategies against pulmonary infectious diseases from a delivery point of view. GRAPHICAL ABSTRACT: [Image: see text] BioMed Central 2022-03-03 /pmc/articles/PMC8892824/ /pubmed/35241085 http://dx.doi.org/10.1186/s12951-022-01307-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
He, Siqin
Gui, Jiajia
Xiong, Kun
Chen, Meiwan
Gao, Huile
Fu, Yao
A roadmap to pulmonary delivery strategies for the treatment of infectious lung diseases
title A roadmap to pulmonary delivery strategies for the treatment of infectious lung diseases
title_full A roadmap to pulmonary delivery strategies for the treatment of infectious lung diseases
title_fullStr A roadmap to pulmonary delivery strategies for the treatment of infectious lung diseases
title_full_unstemmed A roadmap to pulmonary delivery strategies for the treatment of infectious lung diseases
title_short A roadmap to pulmonary delivery strategies for the treatment of infectious lung diseases
title_sort roadmap to pulmonary delivery strategies for the treatment of infectious lung diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892824/
https://www.ncbi.nlm.nih.gov/pubmed/35241085
http://dx.doi.org/10.1186/s12951-022-01307-x
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