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Primary retroperitoneal extraovarian granulosa cell tumor

Extraovarian granulosa cell tumors (GCTs) develop from ectopic gonadal tissue situated along the embryonal route of the genital ridge. Primary retroperitoneal tumors are extremely rare, with an incidence of 02% -06% and 80-85% probability of malignancy. Only eight such case reports have been publish...

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Autores principales: Sharma, Pragya, Singh, Vikram, Mishra, Niharika, Gopinath, Manoj, Gupta, Prashant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hospital Universitário da Universidade de São Paulo 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893158/
https://www.ncbi.nlm.nih.gov/pubmed/35252048
http://dx.doi.org/10.4322/acr.2021.355
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author Sharma, Pragya
Singh, Vikram
Mishra, Niharika
Gopinath, Manoj
Gupta, Prashant
author_facet Sharma, Pragya
Singh, Vikram
Mishra, Niharika
Gopinath, Manoj
Gupta, Prashant
author_sort Sharma, Pragya
collection PubMed
description Extraovarian granulosa cell tumors (GCTs) develop from ectopic gonadal tissue situated along the embryonal route of the genital ridge. Primary retroperitoneal tumors are extremely rare, with an incidence of 02% -06% and 80-85% probability of malignancy. Only eight such case reports have been published previously. We herein, report a rare case of extraovarian retroperitoneal GCT in a 55-year-old woman who presented with intermittent left lumbar region pain of one-year duration. She had a history of hysterectomy and bilateral salpingo-oophorectomy 8 years ago for uterine leiomyoma. Laparotomy revealed a retroperitoneal mass measuring 8cm x 10cm x 20cm in size, solid cystic with areas of necrosis and hemorrhage. The gross features, classical histopathology, and positive immunostaining of the retroperitoneal mass with inhibin, calretinin, PR, WT1 and immunonegativity for EMA were characteristic of adult-type GCT. Excluding any previous history of primary ovarian GCT in this patient, a de-novo retroperitoneal diagnosis was established.
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spelling pubmed-88931582022-03-04 Primary retroperitoneal extraovarian granulosa cell tumor Sharma, Pragya Singh, Vikram Mishra, Niharika Gopinath, Manoj Gupta, Prashant Autops Case Rep Clinical Case Report and Review Extraovarian granulosa cell tumors (GCTs) develop from ectopic gonadal tissue situated along the embryonal route of the genital ridge. Primary retroperitoneal tumors are extremely rare, with an incidence of 02% -06% and 80-85% probability of malignancy. Only eight such case reports have been published previously. We herein, report a rare case of extraovarian retroperitoneal GCT in a 55-year-old woman who presented with intermittent left lumbar region pain of one-year duration. She had a history of hysterectomy and bilateral salpingo-oophorectomy 8 years ago for uterine leiomyoma. Laparotomy revealed a retroperitoneal mass measuring 8cm x 10cm x 20cm in size, solid cystic with areas of necrosis and hemorrhage. The gross features, classical histopathology, and positive immunostaining of the retroperitoneal mass with inhibin, calretinin, PR, WT1 and immunonegativity for EMA were characteristic of adult-type GCT. Excluding any previous history of primary ovarian GCT in this patient, a de-novo retroperitoneal diagnosis was established. Hospital Universitário da Universidade de São Paulo 2022-02-11 /pmc/articles/PMC8893158/ /pubmed/35252048 http://dx.doi.org/10.4322/acr.2021.355 Text en Copyright © 2022 The Author(s). https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Case Report and Review
Sharma, Pragya
Singh, Vikram
Mishra, Niharika
Gopinath, Manoj
Gupta, Prashant
Primary retroperitoneal extraovarian granulosa cell tumor
title Primary retroperitoneal extraovarian granulosa cell tumor
title_full Primary retroperitoneal extraovarian granulosa cell tumor
title_fullStr Primary retroperitoneal extraovarian granulosa cell tumor
title_full_unstemmed Primary retroperitoneal extraovarian granulosa cell tumor
title_short Primary retroperitoneal extraovarian granulosa cell tumor
title_sort primary retroperitoneal extraovarian granulosa cell tumor
topic Clinical Case Report and Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893158/
https://www.ncbi.nlm.nih.gov/pubmed/35252048
http://dx.doi.org/10.4322/acr.2021.355
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