Cargando…

No Evidence That Genetic Variation at the Klotho Locus Is Associated With Longevity in Caucasians from the Newcastle 85+ Study and the UK Biobank

The demographics of Western populations are changing, with an increase in the proportion of older adults. There is evidence to suggest that genetic factors may influence the aging process: studying these may lead to interventions to help individuals live a longer and healthier life. Evidence from se...

Descripción completa

Detalles Bibliográficos
Autores principales:	Amin, Hasnat A, Cordell, Heather J, Martin-Ruiz, Carmen, Robinson, Louise, Kirkwood, Tom, Blakemore, Alexandra I, Drenos, Fotios
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	THE JOURNAL OF GERONTOLOGY: Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893196/ https://www.ncbi.nlm.nih.gov/pubmed/34893828 http://dx.doi.org/10.1093/gerona/glab361

Ejemplares similares

A Frailty Index for UK Biobank Participants
por: Williams, Dylan M, et al.
Publicado: (2019)

Mendelian randomisation analyses of UK Biobank and published data suggest that increased adiposity lowers risk of breast and prostate cancer
por: Amin, Hasnat A., et al.
Publicado: (2022)

Elevated Total Homocysteine in All Participants and Plasma Vitamin B12 Concentrations in Women Are Associated With All-Cause and Cardiovascular Mortality in the Very Old: The Newcastle 85+ Study
por: Mendonça, Nuno, et al.
Publicado: (2018)

On the Definition of Sarcopenia in the Presence of Aging and Obesity—Initial Results from UK Biobank
por: Linge, Jennifer, et al.
Publicado: (2020)

Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort
por: Atkins, Janice L, et al.
Publicado: (2020)

Biological Aging Predicts Vulnerability to COVID-19 Severity in UK Biobank Participants
por: Kuo, Chia-Ling, et al.
Publicado: (2021)

The Association of Physical Activity Behaviors and Patterns With Aging Acceleration: Evidence From the UK Biobank
por: Zhu, Jianwei, et al.
Publicado: (2023)

ApoE e4e4 Genotype and Mortality With COVID-19 in UK Biobank
por: Kuo, Chia-Ling, et al.
Publicado: (2020)

APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort
por: Kuo, Chia-Ling, et al.
Publicado: (2020)

A Biomarker-based Biological Age in UK Biobank: Composition and Prediction of Mortality and Hospital Admissions
por: Chan, Mei Sum, et al.
Publicado: (2021)

Visual Impairment and Risk of Dementia in 2 Population-Based Prospective Cohorts: UK Biobank and EPIC-Norfolk
por: Littlejohns, Thomas J, et al.
Publicado: (2021)

Linear and Nonlinear Associations Between Vitamin D and Grip Strength: A Mendelian Randomization Study in UK Biobank
por: Pinto Pereira, Snehal M, et al.
Publicado: (2022)

Hereditary Hemochromatosis Associations with Frailty, Sarcopenia and Chronic Pain: Evidence from 200,975 Older UK Biobank Participants
por: Tamosauskaite, Jone, et al.
Publicado: (2019)

Comment on “ApoE e4e4 Genotype and Mortality With COVID-19 in UK Biobank” by Kuo et al
por: Nikogosov, Dimitri A, et al.
Publicado: (2020)

Response to Comment on “ApoE e4e4 Genotype and Mortality With COVID-19 in UK Biobank” by Kuo et al.
por: Kuo, Chia-Ling, et al.
Publicado: (2020)

Resistance to Stress Can Be Experimentally Dissociated From Longevity
por: Dues, Dylan J, et al.
Publicado: (2019)

Reproductive Longevity and Aging: Geroscience Approaches to Maintain Long-Term Ovarian Fitness
por: Llarena, Natalia, et al.
Publicado: (2020)

Polygenic Risk Score of Longevity Predicts Longer Survival Across an Age Continuum
por: Tesi, Niccolo’, et al.
Publicado: (2020)

Loneliness in Later Life and Reaching Longevity: Findings From the Longitudinal Aging Study Amsterdam
por: Brandts, Lloyd, et al.
Publicado: (2020)

Income-Related Inequalities in Informal Care: Evidence From the Longitudinal Healthy Longevity Survey in China
por: Wang, Yixiao, et al.
Publicado: (2021)

Protein Restriction Effects on Healthspan and Lifespan in Drosophila melanogaster Are Additive With a Longevity-Promoting Diet
por: Zhang, Wei, et al.
Publicado: (2023)

Developmental Diet Alters the Fecundity–Longevity Relationship and Age-Related Gene Expression in Drosophila melanogaster
por: Collins, David H, et al.
Publicado: (2023)

Exome-Wide Association Study Identifies FN3KRP and PGP as New Candidate Longevity Genes
por: Torres, Guillermo G, et al.
Publicado: (2021)

The Association Between Longevity-Associated FOXO3 Allele and Heart Disease in Septuagenarians and Octogenarians: The SONIC Study
por: Klinpudtan, Nonglak, et al.
Publicado: (2021)

Longevity Around the Turn of the 20th Century: Life-Long Sustained Survival Advantage for Parents of Today’s Nonagenarians
por: van den Berg, Niels, et al.
Publicado: (2018)

Trends in Frailty Between 1990 and 2020 in Sweden Among 75-, 85-, and 95-Year-Old Women and Men: A Nationwide Study from Sweden
por: Wennberg, Alexandra M, et al.
Publicado: (2022)

Respiratory health and disease in a UK population-based cohort of 85 year olds: The Newcastle 85+ Study
por: Fisher, Andrew J, et al.
Publicado: (2016)

The ApoE Locus and COVID-19: Are We Going Where We Have Been?
por: Finch, Caleb E, et al.
Publicado: (2020)

Selection on Alleles Affecting Human Longevity and Late-Life Disease: The Example of Apolipoprotein E
por: Drenos, Fotios, et al.
Publicado: (2010)

Association Between Free-Living Sit-to-Stand Transition Characteristics, and Lower-Extremity Performance, Fear of Falling, and Stair Negotiation Difficulties Among Community-Dwelling 75 to 85-Year-Old Adults
por: Löppönen, Antti, et al.
Publicado: (2022)

Polygenic Propensity for Longevity, APOE-ε4 Status, Dementia Diagnosis, and Risk for Cause-Specific Mortality: A Large Population-Based Longitudinal Study of Older Adults
por: Ajnakina, Olesya, et al.
Publicado: (2023)

No evidence that vitamin D is able to prevent or affect the severity of COVID-19 in individuals with European ancestry: a Mendelian randomisation study of open data
por: Amin, Hasnat A, et al.
Publicado: (2021)

The Association Between Informal Caregiving and Exit From Employment Among Older Workers: Prospective Findings From the UK Household Longitudinal Study
por: Carr, Ewan, et al.
Publicado: (2018)

APOE e4 Genotypes Increase Risk of Delirium During COVID-19-Related Hospitalizations: Evidence From a Large UK Cohort
por: Kuo, Chia-Ling, et al.
Publicado: (2021)

Comparison of cephalometric norms of caucasians and non-caucasians: A forensic aid in ethnic determination
por: Kavitha, L, et al.
Publicado: (2012)

Prevalence of left ventricular dysfunction in a UK community sample of very old people: the Newcastle 85+ study
por: Yousaf, Fahad, et al.
Publicado: (2012)

Health and disease in 85 year olds: baseline findings from the Newcastle 85+ cohort study
por: Collerton, Joanna, et al.
Publicado: (2009)

The enduring effect of education-socioeconomic differences in disability trajectories from age 85 years in the Newcastle 85+ Study
por: Kingston, Andrew, et al.
Publicado: (2015)

Dietary Patterns and Socioeconomic Status in the Very Old: The Newcastle 85+ Study
por: Granic, Antoneta, et al.
Publicado: (2015)

The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians
por: Freathy, Rachel M, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_lhurpb460bmfnr1nijl35ehd6i