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How does a small molecule bind at a cryptic binding site?

Protein-protein interactions (PPIs) are ubiquitous biomolecular processes that are central to virtually all aspects of cellular function. Identifying small molecules that modulate specific disease-related PPIs is a strategy with enormous promise for drug discovery. The design of drugs to disrupt PPI...

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Detalles Bibliográficos
Autores principales:	Shan, Yibing, Mysore, Venkatesh P., Leffler, Abba E., Kim, Eric T., Sagawa, Shiori, Shaw, David E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893328/ https://www.ncbi.nlm.nih.gov/pubmed/35239648 http://dx.doi.org/10.1371/journal.pcbi.1009817

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