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Pneumocystis jirovecii Pneumonia in Three Patients With Breast Cancer Receiving Neoadjuvant Dose-Dense Chemotherapy

We report three cases of Pneumocystis jirovecii pneumonia (PJP) during dose-dense neoadjuvant chemotherapy for breast cancer. All patients presented with symptoms (e.g., fever), and computed tomography showed diffuse ground-glass shadows. Bronchoalveolar lavage was performed, and the diagnosis was c...

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Autores principales: Shiiba, Ritsuya, Himeji, Daisuke, Matsumoto, Ryoichi, Tanaka, Gen-ichi, Otomo, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893678/
https://www.ncbi.nlm.nih.gov/pubmed/35261832
http://dx.doi.org/10.7759/cureus.21812
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author Shiiba, Ritsuya
Himeji, Daisuke
Matsumoto, Ryoichi
Tanaka, Gen-ichi
Otomo, Naoki
author_facet Shiiba, Ritsuya
Himeji, Daisuke
Matsumoto, Ryoichi
Tanaka, Gen-ichi
Otomo, Naoki
author_sort Shiiba, Ritsuya
collection PubMed
description We report three cases of Pneumocystis jirovecii pneumonia (PJP) during dose-dense neoadjuvant chemotherapy for breast cancer. All patients presented with symptoms (e.g., fever), and computed tomography showed diffuse ground-glass shadows. Bronchoalveolar lavage was performed, and the diagnosis was confirmed by polymerase chain reaction for Pneumocystis jirovecii. All patients had completed three or four courses of dose-dense epirubicin-cyclophosphamide chemotherapy and received prednisolone for preventing chemo-induced nausea and vomiting. Moreover, lymphocytopenia was observed in all patients. Since the onset of PJP in preoperative neoadjuvant chemotherapy can be life-threatening and leads to delayed surgery, careful consideration of prophylaxis for PJP is required.
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spelling pubmed-88936782022-03-07 Pneumocystis jirovecii Pneumonia in Three Patients With Breast Cancer Receiving Neoadjuvant Dose-Dense Chemotherapy Shiiba, Ritsuya Himeji, Daisuke Matsumoto, Ryoichi Tanaka, Gen-ichi Otomo, Naoki Cureus Infectious Disease We report three cases of Pneumocystis jirovecii pneumonia (PJP) during dose-dense neoadjuvant chemotherapy for breast cancer. All patients presented with symptoms (e.g., fever), and computed tomography showed diffuse ground-glass shadows. Bronchoalveolar lavage was performed, and the diagnosis was confirmed by polymerase chain reaction for Pneumocystis jirovecii. All patients had completed three or four courses of dose-dense epirubicin-cyclophosphamide chemotherapy and received prednisolone for preventing chemo-induced nausea and vomiting. Moreover, lymphocytopenia was observed in all patients. Since the onset of PJP in preoperative neoadjuvant chemotherapy can be life-threatening and leads to delayed surgery, careful consideration of prophylaxis for PJP is required. Cureus 2022-02-01 /pmc/articles/PMC8893678/ /pubmed/35261832 http://dx.doi.org/10.7759/cureus.21812 Text en Copyright © 2022, Shiiba et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Infectious Disease
Shiiba, Ritsuya
Himeji, Daisuke
Matsumoto, Ryoichi
Tanaka, Gen-ichi
Otomo, Naoki
Pneumocystis jirovecii Pneumonia in Three Patients With Breast Cancer Receiving Neoadjuvant Dose-Dense Chemotherapy
title Pneumocystis jirovecii Pneumonia in Three Patients With Breast Cancer Receiving Neoadjuvant Dose-Dense Chemotherapy
title_full Pneumocystis jirovecii Pneumonia in Three Patients With Breast Cancer Receiving Neoadjuvant Dose-Dense Chemotherapy
title_fullStr Pneumocystis jirovecii Pneumonia in Three Patients With Breast Cancer Receiving Neoadjuvant Dose-Dense Chemotherapy
title_full_unstemmed Pneumocystis jirovecii Pneumonia in Three Patients With Breast Cancer Receiving Neoadjuvant Dose-Dense Chemotherapy
title_short Pneumocystis jirovecii Pneumonia in Three Patients With Breast Cancer Receiving Neoadjuvant Dose-Dense Chemotherapy
title_sort pneumocystis jirovecii pneumonia in three patients with breast cancer receiving neoadjuvant dose-dense chemotherapy
topic Infectious Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893678/
https://www.ncbi.nlm.nih.gov/pubmed/35261832
http://dx.doi.org/10.7759/cureus.21812
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