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Atmospheric particulate matter aggravates CNS demyelination through involvement of TLR-4/NF-kB signaling and microglial activation

Atmospheric Particulate Matter (PM) is one of the leading environmental risk factors for the global burden of disease. Increasing epidemiological studies demonstrated that PM plays a significant role in CNS demyelinating disorders; however, there is no direct testimony of this, and yet the molecular...

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Autores principales: Han, Bing, Li, Xing, Ai, Ruo-Song, Deng, Si-Ying, Ye, Ze-Qing, Deng, Xin, Ma, Wen, Xiao, Shun, Wang, Jing-Zhi, Wang, Li-Mei, Xie, Chong, Zhang, Yan, Xu, Yan, Zhang, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893720/
https://www.ncbi.nlm.nih.gov/pubmed/35199645
http://dx.doi.org/10.7554/eLife.72247
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author Han, Bing
Li, Xing
Ai, Ruo-Song
Deng, Si-Ying
Ye, Ze-Qing
Deng, Xin
Ma, Wen
Xiao, Shun
Wang, Jing-Zhi
Wang, Li-Mei
Xie, Chong
Zhang, Yan
Xu, Yan
Zhang, Yuan
author_facet Han, Bing
Li, Xing
Ai, Ruo-Song
Deng, Si-Ying
Ye, Ze-Qing
Deng, Xin
Ma, Wen
Xiao, Shun
Wang, Jing-Zhi
Wang, Li-Mei
Xie, Chong
Zhang, Yan
Xu, Yan
Zhang, Yuan
author_sort Han, Bing
collection PubMed
description Atmospheric Particulate Matter (PM) is one of the leading environmental risk factors for the global burden of disease. Increasing epidemiological studies demonstrated that PM plays a significant role in CNS demyelinating disorders; however, there is no direct testimony of this, and yet the molecular mechanism by which the occurrence remains unclear. Using multiple in vivo and in vitro strategies, in the present study we demonstrate that PM exposure aggravates neuroinflammation, myelin injury, and dysfunction of movement coordination ability via boosting microglial pro-inflammatory activities, in both the pathological demyelination and physiological myelinogenesis animal models. Indeed, pharmacological disturbance combined with RNA-seq and ChIP-seq suggests that TLR-4/NF-kB signaling mediated a core network of genes that control PM-triggered microglia pathogenicity. In summary, our study defines a novel atmospheric environmental mechanism that mediates PM-aggravated microglia pathogenic activities, and establishes a systematic approach for the investigation of the effects of environmental exposure in neurologic disorders.
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spelling pubmed-88937202022-03-04 Atmospheric particulate matter aggravates CNS demyelination through involvement of TLR-4/NF-kB signaling and microglial activation Han, Bing Li, Xing Ai, Ruo-Song Deng, Si-Ying Ye, Ze-Qing Deng, Xin Ma, Wen Xiao, Shun Wang, Jing-Zhi Wang, Li-Mei Xie, Chong Zhang, Yan Xu, Yan Zhang, Yuan eLife Immunology and Inflammation Atmospheric Particulate Matter (PM) is one of the leading environmental risk factors for the global burden of disease. Increasing epidemiological studies demonstrated that PM plays a significant role in CNS demyelinating disorders; however, there is no direct testimony of this, and yet the molecular mechanism by which the occurrence remains unclear. Using multiple in vivo and in vitro strategies, in the present study we demonstrate that PM exposure aggravates neuroinflammation, myelin injury, and dysfunction of movement coordination ability via boosting microglial pro-inflammatory activities, in both the pathological demyelination and physiological myelinogenesis animal models. Indeed, pharmacological disturbance combined with RNA-seq and ChIP-seq suggests that TLR-4/NF-kB signaling mediated a core network of genes that control PM-triggered microglia pathogenicity. In summary, our study defines a novel atmospheric environmental mechanism that mediates PM-aggravated microglia pathogenic activities, and establishes a systematic approach for the investigation of the effects of environmental exposure in neurologic disorders. eLife Sciences Publications, Ltd 2022-02-24 /pmc/articles/PMC8893720/ /pubmed/35199645 http://dx.doi.org/10.7554/eLife.72247 Text en © 2022, Han et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Immunology and Inflammation
Han, Bing
Li, Xing
Ai, Ruo-Song
Deng, Si-Ying
Ye, Ze-Qing
Deng, Xin
Ma, Wen
Xiao, Shun
Wang, Jing-Zhi
Wang, Li-Mei
Xie, Chong
Zhang, Yan
Xu, Yan
Zhang, Yuan
Atmospheric particulate matter aggravates CNS demyelination through involvement of TLR-4/NF-kB signaling and microglial activation
title Atmospheric particulate matter aggravates CNS demyelination through involvement of TLR-4/NF-kB signaling and microglial activation
title_full Atmospheric particulate matter aggravates CNS demyelination through involvement of TLR-4/NF-kB signaling and microglial activation
title_fullStr Atmospheric particulate matter aggravates CNS demyelination through involvement of TLR-4/NF-kB signaling and microglial activation
title_full_unstemmed Atmospheric particulate matter aggravates CNS demyelination through involvement of TLR-4/NF-kB signaling and microglial activation
title_short Atmospheric particulate matter aggravates CNS demyelination through involvement of TLR-4/NF-kB signaling and microglial activation
title_sort atmospheric particulate matter aggravates cns demyelination through involvement of tlr-4/nf-kb signaling and microglial activation
topic Immunology and Inflammation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893720/
https://www.ncbi.nlm.nih.gov/pubmed/35199645
http://dx.doi.org/10.7554/eLife.72247
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