Cargando…

Integrating Combined First Trimester Screening for Preeclampsia into Routine Ultrasound Examination

Introduction The Fetal Medicine Foundation (FMF) London has developed a first trimester screening algorithm for preeclampsia (PE), based on maternal characteristics and past risk factors, mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), and placental growth factor (PlGF). The...

Descripción completa

Detalles Bibliográficos
Autores principales: Trottmann, Fabienne, Mollet, Anne Elena, Amylidi-Mohr, Sofia, Surbek, Daniel, Raio, Luigi, Mosimann, Beatrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893983/
https://www.ncbi.nlm.nih.gov/pubmed/35250382
http://dx.doi.org/10.1055/a-1534-2599
_version_ 1784662530409365504
author Trottmann, Fabienne
Mollet, Anne Elena
Amylidi-Mohr, Sofia
Surbek, Daniel
Raio, Luigi
Mosimann, Beatrice
author_facet Trottmann, Fabienne
Mollet, Anne Elena
Amylidi-Mohr, Sofia
Surbek, Daniel
Raio, Luigi
Mosimann, Beatrice
author_sort Trottmann, Fabienne
collection PubMed
description Introduction The Fetal Medicine Foundation (FMF) London has developed a first trimester screening algorithm for preeclampsia (PE), based on maternal characteristics and past risk factors, mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), and placental growth factor (PlGF). The aim of this study was to determine the feasibility of integrating PE screening into routine practice. Material and Methods All pregnancies with a fetal crown-rump length of 45 – 84 mm presenting to our ultrasound department between January 2014 and September 2020 were included in this analysis. Screening for PE was offered to singleton pregnancies only. The number of screening tests performed in the eligible population was assessed and the reasons for missed screenings identified with the help of the electronic clinical database. SPSS Statistics 25 and GraphPad version 8.0 for Windows were used for statistical analysis. Results 6535 pregnancies were included, 4510 (69.0%) of which were screened for PE. The percentage of patients being offered PE screening increased over the years from 63.1 to 96.7% (r (s)  = 0.96; p = 0.003), while the rate of screenings performed in eligible patients remained stable at a median [range] of 86.2% [78.0 – 91.8%] (p = ns). 2025 (31.0%) pregnancies were not screened for PE, 1306 (64.5%) because they were not eligible for screening. 145 (2.2%) women explicitly declined PE screening; their background risk was lower than that of women who accepted screening. Conclusion Our study shows that integration of PE screening into the routine first trimester ultrasound scan is feasible and widely accepted by pregnant women and health care providers.
format Online
Article
Text
id pubmed-8893983
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Georg Thieme Verlag KG
record_format MEDLINE/PubMed
spelling pubmed-88939832022-03-04 Integrating Combined First Trimester Screening for Preeclampsia into Routine Ultrasound Examination Trottmann, Fabienne Mollet, Anne Elena Amylidi-Mohr, Sofia Surbek, Daniel Raio, Luigi Mosimann, Beatrice Geburtshilfe Frauenheilkd Introduction The Fetal Medicine Foundation (FMF) London has developed a first trimester screening algorithm for preeclampsia (PE), based on maternal characteristics and past risk factors, mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), and placental growth factor (PlGF). The aim of this study was to determine the feasibility of integrating PE screening into routine practice. Material and Methods All pregnancies with a fetal crown-rump length of 45 – 84 mm presenting to our ultrasound department between January 2014 and September 2020 were included in this analysis. Screening for PE was offered to singleton pregnancies only. The number of screening tests performed in the eligible population was assessed and the reasons for missed screenings identified with the help of the electronic clinical database. SPSS Statistics 25 and GraphPad version 8.0 for Windows were used for statistical analysis. Results 6535 pregnancies were included, 4510 (69.0%) of which were screened for PE. The percentage of patients being offered PE screening increased over the years from 63.1 to 96.7% (r (s)  = 0.96; p = 0.003), while the rate of screenings performed in eligible patients remained stable at a median [range] of 86.2% [78.0 – 91.8%] (p = ns). 2025 (31.0%) pregnancies were not screened for PE, 1306 (64.5%) because they were not eligible for screening. 145 (2.2%) women explicitly declined PE screening; their background risk was lower than that of women who accepted screening. Conclusion Our study shows that integration of PE screening into the routine first trimester ultrasound scan is feasible and widely accepted by pregnant women and health care providers. Georg Thieme Verlag KG 2022-03-03 /pmc/articles/PMC8893983/ /pubmed/35250382 http://dx.doi.org/10.1055/a-1534-2599 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Trottmann, Fabienne
Mollet, Anne Elena
Amylidi-Mohr, Sofia
Surbek, Daniel
Raio, Luigi
Mosimann, Beatrice
Integrating Combined First Trimester Screening for Preeclampsia into Routine Ultrasound Examination
title Integrating Combined First Trimester Screening for Preeclampsia into Routine Ultrasound Examination
title_full Integrating Combined First Trimester Screening for Preeclampsia into Routine Ultrasound Examination
title_fullStr Integrating Combined First Trimester Screening for Preeclampsia into Routine Ultrasound Examination
title_full_unstemmed Integrating Combined First Trimester Screening for Preeclampsia into Routine Ultrasound Examination
title_short Integrating Combined First Trimester Screening for Preeclampsia into Routine Ultrasound Examination
title_sort integrating combined first trimester screening for preeclampsia into routine ultrasound examination
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893983/
https://www.ncbi.nlm.nih.gov/pubmed/35250382
http://dx.doi.org/10.1055/a-1534-2599
work_keys_str_mv AT trottmannfabienne integratingcombinedfirsttrimesterscreeningforpreeclampsiaintoroutineultrasoundexamination
AT molletanneelena integratingcombinedfirsttrimesterscreeningforpreeclampsiaintoroutineultrasoundexamination
AT amylidimohrsofia integratingcombinedfirsttrimesterscreeningforpreeclampsiaintoroutineultrasoundexamination
AT surbekdaniel integratingcombinedfirsttrimesterscreeningforpreeclampsiaintoroutineultrasoundexamination
AT raioluigi integratingcombinedfirsttrimesterscreeningforpreeclampsiaintoroutineultrasoundexamination
AT mosimannbeatrice integratingcombinedfirsttrimesterscreeningforpreeclampsiaintoroutineultrasoundexamination