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Administration of Antenatal Corticosteroids: Current State of Knowledge

The administration of a single course of corticosteroids before week 34 + 0 of gestation in cases with impending preterm birth is now standard procedure in obstetric care and firmly established in the guidelines of different countries. But despite the apparently convincing data, numerous aspects of...

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Autores principales: Berger, Richard, Kyvernitakis, Ioannis, Maul, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893986/
https://www.ncbi.nlm.nih.gov/pubmed/35250378
http://dx.doi.org/10.1055/a-1555-3444
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author Berger, Richard
Kyvernitakis, Ioannis
Maul, Holger
author_facet Berger, Richard
Kyvernitakis, Ioannis
Maul, Holger
author_sort Berger, Richard
collection PubMed
description The administration of a single course of corticosteroids before week 34 + 0 of gestation in cases with impending preterm birth is now standard procedure in obstetric care and firmly established in the guidelines of different countries. But despite the apparently convincing data, numerous aspects of this intervention have not yet been properly studied. It is still not clear which corticosteroid achieves the best results. There are very few studies on what constitutes an appropriate dose, circadian rhythms, the time frame in which corticosteroids are effective, and the balance between the risks and benefits of repeat administration. As the existing studies have rarely included patients before week 24 + 0 of gestation, we have very little information on the possible benefits of administering corticosteroids before this timepoint. If corticosteroids are administered antenatally after week 34 + 0 of gestation, the short-term benefit may be offset by the long-term adverse effect on psychomotor development. This present study summarizes the current state of knowledge regarding these issues.
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spelling pubmed-88939862022-03-04 Administration of Antenatal Corticosteroids: Current State of Knowledge Berger, Richard Kyvernitakis, Ioannis Maul, Holger Geburtshilfe Frauenheilkd The administration of a single course of corticosteroids before week 34 + 0 of gestation in cases with impending preterm birth is now standard procedure in obstetric care and firmly established in the guidelines of different countries. But despite the apparently convincing data, numerous aspects of this intervention have not yet been properly studied. It is still not clear which corticosteroid achieves the best results. There are very few studies on what constitutes an appropriate dose, circadian rhythms, the time frame in which corticosteroids are effective, and the balance between the risks and benefits of repeat administration. As the existing studies have rarely included patients before week 24 + 0 of gestation, we have very little information on the possible benefits of administering corticosteroids before this timepoint. If corticosteroids are administered antenatally after week 34 + 0 of gestation, the short-term benefit may be offset by the long-term adverse effect on psychomotor development. This present study summarizes the current state of knowledge regarding these issues. Georg Thieme Verlag KG 2022-01-11 /pmc/articles/PMC8893986/ /pubmed/35250378 http://dx.doi.org/10.1055/a-1555-3444 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Berger, Richard
Kyvernitakis, Ioannis
Maul, Holger
Administration of Antenatal Corticosteroids: Current State of Knowledge
title Administration of Antenatal Corticosteroids: Current State of Knowledge
title_full Administration of Antenatal Corticosteroids: Current State of Knowledge
title_fullStr Administration of Antenatal Corticosteroids: Current State of Knowledge
title_full_unstemmed Administration of Antenatal Corticosteroids: Current State of Knowledge
title_short Administration of Antenatal Corticosteroids: Current State of Knowledge
title_sort administration of antenatal corticosteroids: current state of knowledge
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893986/
https://www.ncbi.nlm.nih.gov/pubmed/35250378
http://dx.doi.org/10.1055/a-1555-3444
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