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Research Progress and Treatment Status of Liver Cirrhosis with Hypoproteinemia
Liver cirrhosis is the 14th leading cause of death in adults worldwide. The liver is an important organ for the metabolism of sugar, protein, and fat. Liver cirrhosis with hypoproteinemia (LCH) can lead to metabolic disorders of the nutrients such as sugar, protein, and fat, as well as insufficient...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893996/ https://www.ncbi.nlm.nih.gov/pubmed/35251204 http://dx.doi.org/10.1155/2022/2245491 |
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author | Wen, Jianxia Chen, Xing Wei, Shizhang Ma, Xiao Zhao, Yanling |
author_facet | Wen, Jianxia Chen, Xing Wei, Shizhang Ma, Xiao Zhao, Yanling |
author_sort | Wen, Jianxia |
collection | PubMed |
description | Liver cirrhosis is the 14th leading cause of death in adults worldwide. The liver is an important organ for the metabolism of sugar, protein, and fat. Liver cirrhosis with hypoproteinemia (LCH) can lead to metabolic disorders of the nutrients such as sugar, protein, and fat, as well as insufficient protein intake, digestion and absorption disorders, and continuous leakage of plasma protein into the abdominal cavity. Severe hypoproteinemia leads to a poor prognosis in patients. For every 10 g/L decrease in peripheral blood albumin, the risk of secondary liver disease complications will increase by 89% and the mortality rate increased by 24%–56%. Therefore, it is necessary to take urgent measures to treat liver cirrhosis with hypoalbuminemia and effectively treat and reverse the deterioration of the disease caused by hypoalbuminemia, so as to reduce the burden of secondary liver disease. Emerging evidence suggests that protein balance disorders, auxin resistance, and hyperleptinemia are key steps in the development of cirrhosis and hypoproteinemia. This study comprehensively analyzed the common complications, pathogenic mechanisms, and treatment status of cirrhosis caused by hypoproteinemia and proposed research prospects for dealing with this increasingly serious problem. |
format | Online Article Text |
id | pubmed-8893996 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-88939962022-03-04 Research Progress and Treatment Status of Liver Cirrhosis with Hypoproteinemia Wen, Jianxia Chen, Xing Wei, Shizhang Ma, Xiao Zhao, Yanling Evid Based Complement Alternat Med Review Article Liver cirrhosis is the 14th leading cause of death in adults worldwide. The liver is an important organ for the metabolism of sugar, protein, and fat. Liver cirrhosis with hypoproteinemia (LCH) can lead to metabolic disorders of the nutrients such as sugar, protein, and fat, as well as insufficient protein intake, digestion and absorption disorders, and continuous leakage of plasma protein into the abdominal cavity. Severe hypoproteinemia leads to a poor prognosis in patients. For every 10 g/L decrease in peripheral blood albumin, the risk of secondary liver disease complications will increase by 89% and the mortality rate increased by 24%–56%. Therefore, it is necessary to take urgent measures to treat liver cirrhosis with hypoalbuminemia and effectively treat and reverse the deterioration of the disease caused by hypoalbuminemia, so as to reduce the burden of secondary liver disease. Emerging evidence suggests that protein balance disorders, auxin resistance, and hyperleptinemia are key steps in the development of cirrhosis and hypoproteinemia. This study comprehensively analyzed the common complications, pathogenic mechanisms, and treatment status of cirrhosis caused by hypoproteinemia and proposed research prospects for dealing with this increasingly serious problem. Hindawi 2022-02-24 /pmc/articles/PMC8893996/ /pubmed/35251204 http://dx.doi.org/10.1155/2022/2245491 Text en Copyright © 2022 Jianxia Wen et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Wen, Jianxia Chen, Xing Wei, Shizhang Ma, Xiao Zhao, Yanling Research Progress and Treatment Status of Liver Cirrhosis with Hypoproteinemia |
title | Research Progress and Treatment Status of Liver Cirrhosis with Hypoproteinemia |
title_full | Research Progress and Treatment Status of Liver Cirrhosis with Hypoproteinemia |
title_fullStr | Research Progress and Treatment Status of Liver Cirrhosis with Hypoproteinemia |
title_full_unstemmed | Research Progress and Treatment Status of Liver Cirrhosis with Hypoproteinemia |
title_short | Research Progress and Treatment Status of Liver Cirrhosis with Hypoproteinemia |
title_sort | research progress and treatment status of liver cirrhosis with hypoproteinemia |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893996/ https://www.ncbi.nlm.nih.gov/pubmed/35251204 http://dx.doi.org/10.1155/2022/2245491 |
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