Synthesis, Carbonic Anhydrase II/IX/XII Inhibition, DFT, and Molecular Docking Studies of Hydrazide-Sulfonamide Hybrids of 4-Methylsalicyl- and Acyl-Substituted Hydrazide

Carbonic anhydrases (CAs and EC 4.2.1.1) are the Zn(2+) containing enzymes which catalyze the reversible hydration of CO(2) to carbonate and proton. If they are not functioning properly, it would lead towards many diseases including tumor. Synthesis of hydrazide-sulfonamide hybrids (19-36) was carri...

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Detalles Bibliográficos
Autores principales: Khushal, Adil, Mumtaz, Amara, Shadoul, Wamda Ahmed, Zaidi, Syeda Huda Mehdi, Rafique, Hummera, Munir, Abida, Maalik, Aneela, Shah, Syed Jawad Ali, Baig, Ayesha, Khawaja, Wajiha, al-Rashida, Mariya, Hashmi, Muhammad Ali, Iqbal, Jamshed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894010/
https://www.ncbi.nlm.nih.gov/pubmed/35252449
http://dx.doi.org/10.1155/2022/5293349

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