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Perinatal Hyperoxia and Developmental Consequences on the Lung-Brain Axis

Approximately 11.1% of all newborns worldwide are born preterm. Improved neonatal intensive care significantly increased survival rates over the last decades but failed to reduce the risk for the development of chronic lung disease (i.e., bronchopulmonary dysplasia (BPD)) and impaired neurodevelopme...

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Autores principales: Obst, Stefanie, Herz, Josephine, Alejandre Alcazar, Miguel A., Endesfelder, Stefanie, Möbius, Marius A., Rüdiger, Mario, Felderhoff-Müser, Ursula, Bendix, Ivo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894035/
https://www.ncbi.nlm.nih.gov/pubmed/35251477
http://dx.doi.org/10.1155/2022/5784146
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author Obst, Stefanie
Herz, Josephine
Alejandre Alcazar, Miguel A.
Endesfelder, Stefanie
Möbius, Marius A.
Rüdiger, Mario
Felderhoff-Müser, Ursula
Bendix, Ivo
author_facet Obst, Stefanie
Herz, Josephine
Alejandre Alcazar, Miguel A.
Endesfelder, Stefanie
Möbius, Marius A.
Rüdiger, Mario
Felderhoff-Müser, Ursula
Bendix, Ivo
author_sort Obst, Stefanie
collection PubMed
description Approximately 11.1% of all newborns worldwide are born preterm. Improved neonatal intensive care significantly increased survival rates over the last decades but failed to reduce the risk for the development of chronic lung disease (i.e., bronchopulmonary dysplasia (BPD)) and impaired neurodevelopment (i.e., encephalopathy of prematurity (EoP)), two major long-term sequelae of prematurity. Premature infants are exposed to relative hyperoxia, when compared to physiological in-utero conditions and, if needed to additional therapeutic oxygen supplementation. Both are associated with an increased risk for impaired organ development. Since the detrimental effects of hyperoxia on the immature retina are known for many years, lung and brain have come into focus in the last decade. Hyperoxia-induced excessive production of reactive oxygen species leading to oxidative stress and inflammation contribute to pulmonary growth restriction and abnormal neurodevelopment, including myelination deficits. Despite a large body of studies, which unraveled important pathophysiological mechanisms for both organs at risk, the majority focused exclusively either on lung or on brain injury. However, considering that preterm infants suffering from BPD are at higher risk for poor neurodevelopmental outcome, an interaction between both organs seems plausible. This review summarizes recent findings regarding mechanisms of hyperoxia-induced neonatal lung and brain injury. We will discuss common pathophysiological pathways, which potentially link both injured organ systems. Furthermore, promises and needs of currently suggested therapies, including pharmacological and regenerative cell-based treatments for BPD and EoP, will be emphasized. Limited therapeutic approaches highlight the urgent need for a better understanding of the mechanisms underlying detrimental effects of hyperoxia on the lung-brain axis in order to pave the way for the development of novel multimodal therapies, ideally targeting both severe preterm birth-associated complications.
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spelling pubmed-88940352022-03-04 Perinatal Hyperoxia and Developmental Consequences on the Lung-Brain Axis Obst, Stefanie Herz, Josephine Alejandre Alcazar, Miguel A. Endesfelder, Stefanie Möbius, Marius A. Rüdiger, Mario Felderhoff-Müser, Ursula Bendix, Ivo Oxid Med Cell Longev Review Article Approximately 11.1% of all newborns worldwide are born preterm. Improved neonatal intensive care significantly increased survival rates over the last decades but failed to reduce the risk for the development of chronic lung disease (i.e., bronchopulmonary dysplasia (BPD)) and impaired neurodevelopment (i.e., encephalopathy of prematurity (EoP)), two major long-term sequelae of prematurity. Premature infants are exposed to relative hyperoxia, when compared to physiological in-utero conditions and, if needed to additional therapeutic oxygen supplementation. Both are associated with an increased risk for impaired organ development. Since the detrimental effects of hyperoxia on the immature retina are known for many years, lung and brain have come into focus in the last decade. Hyperoxia-induced excessive production of reactive oxygen species leading to oxidative stress and inflammation contribute to pulmonary growth restriction and abnormal neurodevelopment, including myelination deficits. Despite a large body of studies, which unraveled important pathophysiological mechanisms for both organs at risk, the majority focused exclusively either on lung or on brain injury. However, considering that preterm infants suffering from BPD are at higher risk for poor neurodevelopmental outcome, an interaction between both organs seems plausible. This review summarizes recent findings regarding mechanisms of hyperoxia-induced neonatal lung and brain injury. We will discuss common pathophysiological pathways, which potentially link both injured organ systems. Furthermore, promises and needs of currently suggested therapies, including pharmacological and regenerative cell-based treatments for BPD and EoP, will be emphasized. Limited therapeutic approaches highlight the urgent need for a better understanding of the mechanisms underlying detrimental effects of hyperoxia on the lung-brain axis in order to pave the way for the development of novel multimodal therapies, ideally targeting both severe preterm birth-associated complications. Hindawi 2022-02-24 /pmc/articles/PMC8894035/ /pubmed/35251477 http://dx.doi.org/10.1155/2022/5784146 Text en Copyright © 2022 Stefanie Obst et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Obst, Stefanie
Herz, Josephine
Alejandre Alcazar, Miguel A.
Endesfelder, Stefanie
Möbius, Marius A.
Rüdiger, Mario
Felderhoff-Müser, Ursula
Bendix, Ivo
Perinatal Hyperoxia and Developmental Consequences on the Lung-Brain Axis
title Perinatal Hyperoxia and Developmental Consequences on the Lung-Brain Axis
title_full Perinatal Hyperoxia and Developmental Consequences on the Lung-Brain Axis
title_fullStr Perinatal Hyperoxia and Developmental Consequences on the Lung-Brain Axis
title_full_unstemmed Perinatal Hyperoxia and Developmental Consequences on the Lung-Brain Axis
title_short Perinatal Hyperoxia and Developmental Consequences on the Lung-Brain Axis
title_sort perinatal hyperoxia and developmental consequences on the lung-brain axis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894035/
https://www.ncbi.nlm.nih.gov/pubmed/35251477
http://dx.doi.org/10.1155/2022/5784146
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