Shikinefragalides A-D, new tricyclic macrolides produced by Stachybotryaceae sp. FKI-9632

Four new tricyclic macrolides, named shikinefragalides A (1), B (2), C (3) and D (4), were isolated by physicochemical (PC) screening from a static culture material of Stachybotryaceae sp. FKI-9632. Their structures were elucidated as new analogs of colletofragarones by MS and NMR analyses. Compound...

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Autores principales: Koike, Rima, Watanabe, Yoshihiro, Kato, Kazuho, Mikasa, Yudai, Shimizu, Kota, Nonaka, Kenichi, Honsho, Masako, Suga, Takuya, Hokari, Rei, Ishiyama, Aki, Asami, Yukihiro, Iwatsuki, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894093/
https://www.ncbi.nlm.nih.gov/pubmed/35241792
http://dx.doi.org/10.1038/s41429-022-00512-y
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author Koike, Rima
Watanabe, Yoshihiro
Kato, Kazuho
Mikasa, Yudai
Shimizu, Kota
Nonaka, Kenichi
Honsho, Masako
Suga, Takuya
Hokari, Rei
Ishiyama, Aki
Asami, Yukihiro
Iwatsuki, Masato
author_facet Koike, Rima
Watanabe, Yoshihiro
Kato, Kazuho
Mikasa, Yudai
Shimizu, Kota
Nonaka, Kenichi
Honsho, Masako
Suga, Takuya
Hokari, Rei
Ishiyama, Aki
Asami, Yukihiro
Iwatsuki, Masato
author_sort Koike, Rima
collection PubMed
description Four new tricyclic macrolides, named shikinefragalides A (1), B (2), C (3) and D (4), were isolated by physicochemical (PC) screening from a static culture material of Stachybotryaceae sp. FKI-9632. Their structures were elucidated as new analogs of colletofragarones by MS and NMR analyses. Compounds 1 and 2 showed weak antimalarial activity and cytotoxicity.
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spelling pubmed-88940932022-03-04 Shikinefragalides A-D, new tricyclic macrolides produced by Stachybotryaceae sp. FKI-9632 Koike, Rima Watanabe, Yoshihiro Kato, Kazuho Mikasa, Yudai Shimizu, Kota Nonaka, Kenichi Honsho, Masako Suga, Takuya Hokari, Rei Ishiyama, Aki Asami, Yukihiro Iwatsuki, Masato J Antibiot (Tokyo) Article Four new tricyclic macrolides, named shikinefragalides A (1), B (2), C (3) and D (4), were isolated by physicochemical (PC) screening from a static culture material of Stachybotryaceae sp. FKI-9632. Their structures were elucidated as new analogs of colletofragarones by MS and NMR analyses. Compounds 1 and 2 showed weak antimalarial activity and cytotoxicity. Nature Publishing Group UK 2022-03-04 2022 /pmc/articles/PMC8894093/ /pubmed/35241792 http://dx.doi.org/10.1038/s41429-022-00512-y Text en © The Author(s), under exclusive licence to the Japan Antibiotics Research Association 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Koike, Rima
Watanabe, Yoshihiro
Kato, Kazuho
Mikasa, Yudai
Shimizu, Kota
Nonaka, Kenichi
Honsho, Masako
Suga, Takuya
Hokari, Rei
Ishiyama, Aki
Asami, Yukihiro
Iwatsuki, Masato
Shikinefragalides A-D, new tricyclic macrolides produced by Stachybotryaceae sp. FKI-9632
title Shikinefragalides A-D, new tricyclic macrolides produced by Stachybotryaceae sp. FKI-9632
title_full Shikinefragalides A-D, new tricyclic macrolides produced by Stachybotryaceae sp. FKI-9632
title_fullStr Shikinefragalides A-D, new tricyclic macrolides produced by Stachybotryaceae sp. FKI-9632
title_full_unstemmed Shikinefragalides A-D, new tricyclic macrolides produced by Stachybotryaceae sp. FKI-9632
title_short Shikinefragalides A-D, new tricyclic macrolides produced by Stachybotryaceae sp. FKI-9632
title_sort shikinefragalides a-d, new tricyclic macrolides produced by stachybotryaceae sp. fki-9632
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894093/
https://www.ncbi.nlm.nih.gov/pubmed/35241792
http://dx.doi.org/10.1038/s41429-022-00512-y
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