Cargando…

MicroRNA-128-3p Mediates Lenvatinib Resistance of Hepatocellular Carcinoma Cells by Downregulating c-Met

OBJECTIVE: Lenvatinib is a first-line multikinase inhibitor for advanced hepatocellular carcinoma (HCC), but resistance to the drug remains a major hurdle for its long-term anti-cancer activity. This resistance is thought to be due to overexpression of c-Met. This study aims to identify potential up...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Xin, Jiang, Wenjing, Han, Peng, Zhang, Jingyan, Tong, Liquan, Sun, Xueying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894104/ https://www.ncbi.nlm.nih.gov/pubmed/35252056 http://dx.doi.org/10.2147/JHC.S349369

Ejemplares similares

MicroRNA-128-3p Enhances the Chemosensitivity of Temozolomide in Glioblastoma by Targeting c-Met and EMT
por: Zhao, Chengbin, et al.
Publicado: (2020)

Effect of Lenvatinib treatment on the cell cycle and microRNA profile in hepatocellular carcinoma cells
por: Nakahara, Mai, et al.
Publicado: (2022)

Downregulation of microRNA-132 indicates progression in hepatocellular carcinoma
por: Zhang, Xin, et al.
Publicado: (2016)

Development of a Multivariate Prognostic Model for Lenvatinib Treatment in Hepatocellular Carcinoma
por: Li, Xiaomi, et al.
Publicado: (2023)

miR-128-3p serves as an oncogenic microRNA in osteosarcoma cells by downregulating ZC3H12D
por: Zhu, Maoshu, et al.
Publicado: (2021)

MicroRNA-497-5p Is Downregulated in Hepatocellular Carcinoma and Associated with Tumorigenesis and Poor Prognosis in Patients
por: Tian, Lin-Lin, et al.
Publicado: (2021)

Clinical study of lenvatinib in the treatment of hepatitis virus-related hepatocellular carcinoma and antiviral therapy
por: Li, Xiaomi, et al.
Publicado: (2023)

MicroRNA-552 promotes hepatocellular carcinoma progression by downregulating WIF1
por: Li, Chao, et al.
Publicado: (2018)

microRNA-128a dysregulation in transgenic Huntington’s disease monkeys
por: Kocerha, Jannet, et al.
Publicado: (2014)

Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration
por: Huang, Wei, et al.
Publicado: (2018)

Long Noncoding RNA HCP5 Contributes to Nasopharyngeal Carcinoma Progression by Targeting MicroRNA-128-3p
por: Miao, Gangyong, et al.
Publicado: (2022)

Suppression of CYP2C9 by MicroRNA hsa-miR-128-3p in Human Liver Cells and Association with Hepatocellular Carcinoma
por: Yu, Dianke, et al.
Publicado: (2015)

Overexpression of the lncRNA HOTAIRM1 promotes lenvatinib resistance by downregulating miR-34a and activating autophagy in hepatocellular carcinoma
por: Gu, Danyan, et al.
Publicado: (2023)

MicroRNA-1269 promotes proliferation in human hepatocellular carcinoma via downregulation of FOXO1
por: Yang, Xue-Wei, et al.
Publicado: (2014)

Lenvatinib for Hepatocellular Carcinoma: A Literature Review
por: Hatanaka, Takeshi, et al.
Publicado: (2021)

The role of lenvatinib in the era of immunotherapy of hepatocellular carcinoma
por: Lee, Matthew Man Pok, et al.
Publicado: (2023)

Sorafenib, Lenvatinib, or Lenvatinib Combining PD-1 Inhibitors Plus TACE in Unresectable Hepatocellular Carcinoma: A Retrospective Analysis
por: Zhao, Shu, et al.
Publicado: (2022)

Curcumin-Mediated Resistance to Lenvatinib via EGFR Signaling Pathway in Hepatocellular Carcinoma
por: Miyazaki, Katsuki, et al.
Publicado: (2023)

MicroRNA-182 downregulates metastasis suppressor 1 and contributes to metastasis of hepatocellular carcinoma
por: Wang, Jian, et al.
Publicado: (2012)

microRNA-17 functions as an oncogene by downregulating Smad3 expression in hepatocellular carcinoma
por: Lu, Zhufeng, et al.
Publicado: (2019)

Mutations in microRNA-128-2-3p identified with amplification-free hybridization assay
por: Slott, Sofie, et al.
Publicado: (2023)

MicroRNA-128 suppresses cell growth and metastasis in colorectal carcinoma by targeting IRS1
por: Wu, Lan, et al.
Publicado: (2021)

Prognostic model for predicting outcome and guiding treatment decision for unresectable hepatocellular carcinoma treated with lenvatinib monotherapy or lenvatinib plus immunotherapy
por: Guo, De-Zhen, et al.
Publicado: (2023)

A Perspective on the Role of microRNA-128 Regulation in Mental and Behavioral Disorders
por: Ching, Ai-Sze, et al.
Publicado: (2015)

Inhibition of microRNA 128 promotes excitability of cultured cortical neuronal networks
por: McSweeney, K. Melodi, et al.
Publicado: (2016)

microRNA-128 mediates CB1 expression and regulates NF-KB/p-JNK axis to influence the occurrence of diabetic bladder disease
por: Gou, Xin, et al.
Publicado: (2020)

MicroRNA-466 inhibits cancer cell migration and invasion in hepatocellular carcinoma by indirectly mediating the downregulation of ROCK2
por: Ai, Ning, et al.
Publicado: (2019)

MicroRNA-27b, microRNA-101 and microRNA-128 inhibit angiogenesis by down-regulating vascular endothelial growth factor C expression in gastric cancers
por: Liu, Hai-Ting, et al.
Publicado: (2015)

Lenvatinib, toripalimab, plus hepatic arterial infusion chemotherapy versus lenvatinib alone for advanced hepatocellular carcinoma
por: He, Min-Ke, et al.
Publicado: (2021)

Lenvatinib for the treatment of unresectable hepatocellular carcinoma: evidence to date
por: Personeni, Nicola, et al.
Publicado: (2019)

Therapeutic efficacy of lenvatinib in nonviral unresectable hepatocellular carcinoma
por: Tomonari, Tetsu, et al.
Publicado: (2021)

Analysis of Survival and Response to Lenvatinib in Unresectable Hepatocellular Carcinoma
por: Amioka, Kei, et al.
Publicado: (2022)

Nephrotic Syndrome Induced by Lenvatinib Treatment for Hepatocellular Carcinoma
por: Prasoppokakorn, Thaninee, et al.
Publicado: (2022)

Lenvatinib applicability in the therapeutic strategy of patients with hepatocellular carcinoma
por: Merle, Philippe
Publicado: (2023)

MicroRNA-218 and microRNA-520a inhibit cell proliferation by downregulating E2F2 in hepatocellular carcinoma
por: DONG, YE, et al.
Publicado: (2015)

microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity
por: Zhang, J, et al.
Publicado: (2010)

MicroRNA-499 Suppresses the Growth of Hepatocellular Carcinoma by Downregulating Astrocyte Elevated Gene-1
por: Wang, Jing, et al.
Publicado: (2020)

MicroRNA-377 Downregulates Bcl-xL and Increases Apoptosis in Hepatocellular Carcinoma Cells
por: Ge, Hongyan, et al.
Publicado: (2017)

The Role of MicroRNAs in Hepatocellular Carcinoma
por: Xu, Xin, et al.
Publicado: (2018)

Effects of downregulated expression of microRNA-187 in gastric cancer
por: Chen, Wenjing, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_n5ph7efv24sh462giu352181n9