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The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacy

Cyclic (di)nucleotides act as universal second messengers endogenously produced by several pathogens. Specifically, the roles of c-di-AMP in Mycobacterium tuberculosis immunity and virulence have been largely explored, although its contribution to the safety and efficacy of live tuberculosis vaccine...

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Detalles Bibliográficos
Autores principales:	Pérez, Irene, Campos-Pardos, Elena, Díaz, Caridad, Uranga, Santiago, Sayes, Fadel, Vicente, Francisca, Aguiló, Nacho, Brosch, Roland, Martín, Carlos, Gonzalo-Asensio, Jesús
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894143/ https://www.ncbi.nlm.nih.gov/pubmed/35282413 http://dx.doi.org/10.1016/j.omtn.2022.02.011

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