Biological Frailty Index in centenarians

This study measured the subclinical frailty of centenarians by looking at the accumulation of their biological abnormalities. For this aim, a biological Frailty Index (FI) was computed in centenarians living in Northern Italy. The median value of the biological FI was 0.33 (interquartile range, IQR...

Descripción completa

Detalles Bibliográficos
Autores principales: Arosio, Beatrice, Geraci, Annalisa, Ferri, Evelyn, Mari, Daniela, Cesari, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894165/
https://www.ncbi.nlm.nih.gov/pubmed/34655428
http://dx.doi.org/10.1007/s40520-021-01993-x
_version_ 1784662582549807104
author Arosio, Beatrice
Geraci, Annalisa
Ferri, Evelyn
Mari, Daniela
Cesari, Matteo
author_facet Arosio, Beatrice
Geraci, Annalisa
Ferri, Evelyn
Mari, Daniela
Cesari, Matteo
author_sort Arosio, Beatrice
collection PubMed
description This study measured the subclinical frailty of centenarians by looking at the accumulation of their biological abnormalities. For this aim, a biological Frailty Index (FI) was computed in centenarians living in Northern Italy. The median value of the biological FI was 0.33 (interquartile range, IQR 0.28–0.41). The biological FI did not significantly differ between women (0.34, IQR 0.31–0.39) and men (0.32, IQR 0.26–0.43). The biological FI seems to have a narrower distribution compared to clinical FI we previously computed in the same cohort. In conclusion, our study suggests that centenarians benefit from exceptional biological reserves that might be underestimated by clinical appearances.
format Online
Article
Text
id pubmed-8894165
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-88941652022-03-08 Biological Frailty Index in centenarians Arosio, Beatrice Geraci, Annalisa Ferri, Evelyn Mari, Daniela Cesari, Matteo Aging Clin Exp Res Short Communication This study measured the subclinical frailty of centenarians by looking at the accumulation of their biological abnormalities. For this aim, a biological Frailty Index (FI) was computed in centenarians living in Northern Italy. The median value of the biological FI was 0.33 (interquartile range, IQR 0.28–0.41). The biological FI did not significantly differ between women (0.34, IQR 0.31–0.39) and men (0.32, IQR 0.26–0.43). The biological FI seems to have a narrower distribution compared to clinical FI we previously computed in the same cohort. In conclusion, our study suggests that centenarians benefit from exceptional biological reserves that might be underestimated by clinical appearances. Springer International Publishing 2021-10-16 2022 /pmc/articles/PMC8894165/ /pubmed/34655428 http://dx.doi.org/10.1007/s40520-021-01993-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Short Communication
Arosio, Beatrice
Geraci, Annalisa
Ferri, Evelyn
Mari, Daniela
Cesari, Matteo
Biological Frailty Index in centenarians
title Biological Frailty Index in centenarians
title_full Biological Frailty Index in centenarians
title_fullStr Biological Frailty Index in centenarians
title_full_unstemmed Biological Frailty Index in centenarians
title_short Biological Frailty Index in centenarians
title_sort biological frailty index in centenarians
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894165/
https://www.ncbi.nlm.nih.gov/pubmed/34655428
http://dx.doi.org/10.1007/s40520-021-01993-x
work_keys_str_mv AT arosiobeatrice biologicalfrailtyindexincentenarians
AT geraciannalisa biologicalfrailtyindexincentenarians
AT ferrievelyn biologicalfrailtyindexincentenarians
AT maridaniela biologicalfrailtyindexincentenarians
AT cesarimatteo biologicalfrailtyindexincentenarians

Ejemplares similares