Cargando…

Brain Connectometry Changes in Space Travelers After Long-Duration Spaceflight

Humans undergo extreme physiological changes when subjected to long periods of weightlessness, and as we continue to become a space-faring species, it is imperative that we fully understand the physiological changes that occur in the human body, including the brain. In this study, we present finding...

Descripción completa

Detalles Bibliográficos
Autores principales: Doroshin, Andrei, Jillings, Steven, Jeurissen, Ben, Tomilovskaya, Elena, Pechenkova, Ekaterina, Nosikova, Inna, Rumshiskaya, Alena, Litvinova, Liudmila, Rukavishnikov, Ilya, De Laet, Chloë, Schoenmaekers, Catho, Sijbers, Jan, Laureys, Steven, Petrovichev, Victor, Van Ombergen, Angelique, Annen, Jitka, Sunaert, Stefan, Parizel, Paul M., Sinitsyn, Valentin, zu Eulenburg, Peter, Osipowicz, Karol, Wuyts, Floris L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894205/
https://www.ncbi.nlm.nih.gov/pubmed/35250494
http://dx.doi.org/10.3389/fncir.2022.815838
_version_ 1784662599483260928
author Doroshin, Andrei
Jillings, Steven
Jeurissen, Ben
Tomilovskaya, Elena
Pechenkova, Ekaterina
Nosikova, Inna
Rumshiskaya, Alena
Litvinova, Liudmila
Rukavishnikov, Ilya
De Laet, Chloë
Schoenmaekers, Catho
Sijbers, Jan
Laureys, Steven
Petrovichev, Victor
Van Ombergen, Angelique
Annen, Jitka
Sunaert, Stefan
Parizel, Paul M.
Sinitsyn, Valentin
zu Eulenburg, Peter
Osipowicz, Karol
Wuyts, Floris L.
author_facet Doroshin, Andrei
Jillings, Steven
Jeurissen, Ben
Tomilovskaya, Elena
Pechenkova, Ekaterina
Nosikova, Inna
Rumshiskaya, Alena
Litvinova, Liudmila
Rukavishnikov, Ilya
De Laet, Chloë
Schoenmaekers, Catho
Sijbers, Jan
Laureys, Steven
Petrovichev, Victor
Van Ombergen, Angelique
Annen, Jitka
Sunaert, Stefan
Parizel, Paul M.
Sinitsyn, Valentin
zu Eulenburg, Peter
Osipowicz, Karol
Wuyts, Floris L.
author_sort Doroshin, Andrei
collection PubMed
description Humans undergo extreme physiological changes when subjected to long periods of weightlessness, and as we continue to become a space-faring species, it is imperative that we fully understand the physiological changes that occur in the human body, including the brain. In this study, we present findings of brain structural changes associated with long-duration spaceflight based on diffusion magnetic resonance imaging (dMRI) data. Twelve cosmonauts who spent an average of six months aboard the International Space Station (ISS) were scanned in an MRI scanner pre-flight, ten days after flight, and at a follow-up time point seven months after flight. We performed differential tractography, a technique that confines white matter fiber tracking to voxels showing microstructural changes. We found significant microstructural changes in several large white matter tracts, such as the corpus callosum, arcuate fasciculus, corticospinal, corticostriatal, and cerebellar tracts. This is the first paper to use fiber tractography to investigate which specific tracts exhibit structural changes after long-duration spaceflight and may direct future research to investigate brain functional and behavioral changes associated with these white matter pathways.
format Online
Article
Text
id pubmed-8894205
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-88942052022-03-05 Brain Connectometry Changes in Space Travelers After Long-Duration Spaceflight Doroshin, Andrei Jillings, Steven Jeurissen, Ben Tomilovskaya, Elena Pechenkova, Ekaterina Nosikova, Inna Rumshiskaya, Alena Litvinova, Liudmila Rukavishnikov, Ilya De Laet, Chloë Schoenmaekers, Catho Sijbers, Jan Laureys, Steven Petrovichev, Victor Van Ombergen, Angelique Annen, Jitka Sunaert, Stefan Parizel, Paul M. Sinitsyn, Valentin zu Eulenburg, Peter Osipowicz, Karol Wuyts, Floris L. Front Neural Circuits Neural Circuits Humans undergo extreme physiological changes when subjected to long periods of weightlessness, and as we continue to become a space-faring species, it is imperative that we fully understand the physiological changes that occur in the human body, including the brain. In this study, we present findings of brain structural changes associated with long-duration spaceflight based on diffusion magnetic resonance imaging (dMRI) data. Twelve cosmonauts who spent an average of six months aboard the International Space Station (ISS) were scanned in an MRI scanner pre-flight, ten days after flight, and at a follow-up time point seven months after flight. We performed differential tractography, a technique that confines white matter fiber tracking to voxels showing microstructural changes. We found significant microstructural changes in several large white matter tracts, such as the corpus callosum, arcuate fasciculus, corticospinal, corticostriatal, and cerebellar tracts. This is the first paper to use fiber tractography to investigate which specific tracts exhibit structural changes after long-duration spaceflight and may direct future research to investigate brain functional and behavioral changes associated with these white matter pathways. Frontiers Media S.A. 2022-02-18 /pmc/articles/PMC8894205/ /pubmed/35250494 http://dx.doi.org/10.3389/fncir.2022.815838 Text en Copyright © 2022 Doroshin, Jillings, Jeurissen, Tomilovskaya, Pechenkova, Nosikova, Rumshiskaya, Litvinova, Rukavishnikov, De Laet, Schoenmaekers, Sijbers, Laureys, Petrovichev, Van Ombergen, Annen, Sunaert, Parizel, Sinitsyn, zu Eulenburg, Osipowicz and Wuyts. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neural Circuits
Doroshin, Andrei
Jillings, Steven
Jeurissen, Ben
Tomilovskaya, Elena
Pechenkova, Ekaterina
Nosikova, Inna
Rumshiskaya, Alena
Litvinova, Liudmila
Rukavishnikov, Ilya
De Laet, Chloë
Schoenmaekers, Catho
Sijbers, Jan
Laureys, Steven
Petrovichev, Victor
Van Ombergen, Angelique
Annen, Jitka
Sunaert, Stefan
Parizel, Paul M.
Sinitsyn, Valentin
zu Eulenburg, Peter
Osipowicz, Karol
Wuyts, Floris L.
Brain Connectometry Changes in Space Travelers After Long-Duration Spaceflight
title Brain Connectometry Changes in Space Travelers After Long-Duration Spaceflight
title_full Brain Connectometry Changes in Space Travelers After Long-Duration Spaceflight
title_fullStr Brain Connectometry Changes in Space Travelers After Long-Duration Spaceflight
title_full_unstemmed Brain Connectometry Changes in Space Travelers After Long-Duration Spaceflight
title_short Brain Connectometry Changes in Space Travelers After Long-Duration Spaceflight
title_sort brain connectometry changes in space travelers after long-duration spaceflight
topic Neural Circuits
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894205/
https://www.ncbi.nlm.nih.gov/pubmed/35250494
http://dx.doi.org/10.3389/fncir.2022.815838
work_keys_str_mv AT doroshinandrei brainconnectometrychangesinspacetravelersafterlongdurationspaceflight
AT jillingssteven brainconnectometrychangesinspacetravelersafterlongdurationspaceflight
AT jeurissenben brainconnectometrychangesinspacetravelersafterlongdurationspaceflight
AT tomilovskayaelena brainconnectometrychangesinspacetravelersafterlongdurationspaceflight
AT pechenkovaekaterina brainconnectometrychangesinspacetravelersafterlongdurationspaceflight
AT nosikovainna brainconnectometrychangesinspacetravelersafterlongdurationspaceflight
AT rumshiskayaalena brainconnectometrychangesinspacetravelersafterlongdurationspaceflight
AT litvinovaliudmila brainconnectometrychangesinspacetravelersafterlongdurationspaceflight
AT rukavishnikovilya brainconnectometrychangesinspacetravelersafterlongdurationspaceflight
AT delaetchloe brainconnectometrychangesinspacetravelersafterlongdurationspaceflight
AT schoenmaekerscatho brainconnectometrychangesinspacetravelersafterlongdurationspaceflight
AT sijbersjan brainconnectometrychangesinspacetravelersafterlongdurationspaceflight
AT laureyssteven brainconnectometrychangesinspacetravelersafterlongdurationspaceflight
AT petrovichevvictor brainconnectometrychangesinspacetravelersafterlongdurationspaceflight
AT vanombergenangelique brainconnectometrychangesinspacetravelersafterlongdurationspaceflight
AT annenjitka brainconnectometrychangesinspacetravelersafterlongdurationspaceflight
AT sunaertstefan brainconnectometrychangesinspacetravelersafterlongdurationspaceflight
AT parizelpaulm brainconnectometrychangesinspacetravelersafterlongdurationspaceflight
AT sinitsynvalentin brainconnectometrychangesinspacetravelersafterlongdurationspaceflight
AT zueulenburgpeter brainconnectometrychangesinspacetravelersafterlongdurationspaceflight
AT osipowiczkarol brainconnectometrychangesinspacetravelersafterlongdurationspaceflight
AT wuytsflorisl brainconnectometrychangesinspacetravelersafterlongdurationspaceflight