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Iron deficiency and biomarkers of inflammation: a 3-year prospective analysis of the DO-HEALTH trial
BACKGROUND: The longitudinal association between iron deficiency and inflammatory biomarkers levels has not been fully explored among relatively healthy older adults. AIMS: To assess whether iron deficiency at baseline and at any yearly follow-up time point, with or without anemia, was associated wi...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894209/ https://www.ncbi.nlm.nih.gov/pubmed/34533774 http://dx.doi.org/10.1007/s40520-021-01955-3 |
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author | Wieczorek, Maud Schwarz, Franziska Sadlon, Angélique Abderhalden, Lauren A. de Godoi Rezende Costa Molino, Caroline Spahn, Donat R. Schaer, Dominik J. Orav, E. John Egli, Andreas Bischoff-Ferrari, Heike A. |
author_facet | Wieczorek, Maud Schwarz, Franziska Sadlon, Angélique Abderhalden, Lauren A. de Godoi Rezende Costa Molino, Caroline Spahn, Donat R. Schaer, Dominik J. Orav, E. John Egli, Andreas Bischoff-Ferrari, Heike A. |
author_sort | Wieczorek, Maud |
collection | PubMed |
description | BACKGROUND: The longitudinal association between iron deficiency and inflammatory biomarkers levels has not been fully explored among relatively healthy older adults. AIMS: To assess whether iron deficiency at baseline and at any yearly follow-up time point, with or without anemia, was associated with changes from baseline in high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) levels over 3 years. METHODS: This is a post-hoc observational analysis of DO-HEALTH, a double-blind, randomized controlled trial including 2157 European community-dwelling adults age 70+. The outcomes were changes from baseline in hs-CRP and IL-6 levels, measured at 12, 24, and 36 months of follow-up. Iron deficiency was defined by soluble transferrin receptor levels > 28.1 nmol/L and baseline anemia by hemoglobin levels < 130 g/L for men and < 120 g/L for women. RESULTS: In total, 2141 participants were included in the analyses (mean age: 74.9 years, 61.5% of women, 26.8% with iron deficiency). Baseline iron deficiency was associated with greater increase in IL-6 levels (mean difference in change: 0.52 ng/L, 95%CI 0.03–1.00, P = .04) over 3 years. Iron deficiency at any yearly time point was associated with higher increases in hs-CRP (mean difference in change: 1.62 mg/L, 95%CI 0.98–2.26, P < .001) and IL-6 levels (mean difference in change: 1.33 ng/L, 95%CI 0.87–1.79, P < .001) over 3 years. No significant interaction between iron deficiency and anemia was found, suggesting that the results are independent of the anemic status. CONCLUSIONS: These findings suggest that iron deficiency may play a role in low-grade chronic inflammation among relatively healthy older adults. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40520-021-01955-3. |
format | Online Article Text |
id | pubmed-8894209 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-88942092022-03-08 Iron deficiency and biomarkers of inflammation: a 3-year prospective analysis of the DO-HEALTH trial Wieczorek, Maud Schwarz, Franziska Sadlon, Angélique Abderhalden, Lauren A. de Godoi Rezende Costa Molino, Caroline Spahn, Donat R. Schaer, Dominik J. Orav, E. John Egli, Andreas Bischoff-Ferrari, Heike A. Aging Clin Exp Res Original Article BACKGROUND: The longitudinal association between iron deficiency and inflammatory biomarkers levels has not been fully explored among relatively healthy older adults. AIMS: To assess whether iron deficiency at baseline and at any yearly follow-up time point, with or without anemia, was associated with changes from baseline in high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) levels over 3 years. METHODS: This is a post-hoc observational analysis of DO-HEALTH, a double-blind, randomized controlled trial including 2157 European community-dwelling adults age 70+. The outcomes were changes from baseline in hs-CRP and IL-6 levels, measured at 12, 24, and 36 months of follow-up. Iron deficiency was defined by soluble transferrin receptor levels > 28.1 nmol/L and baseline anemia by hemoglobin levels < 130 g/L for men and < 120 g/L for women. RESULTS: In total, 2141 participants were included in the analyses (mean age: 74.9 years, 61.5% of women, 26.8% with iron deficiency). Baseline iron deficiency was associated with greater increase in IL-6 levels (mean difference in change: 0.52 ng/L, 95%CI 0.03–1.00, P = .04) over 3 years. Iron deficiency at any yearly time point was associated with higher increases in hs-CRP (mean difference in change: 1.62 mg/L, 95%CI 0.98–2.26, P < .001) and IL-6 levels (mean difference in change: 1.33 ng/L, 95%CI 0.87–1.79, P < .001) over 3 years. No significant interaction between iron deficiency and anemia was found, suggesting that the results are independent of the anemic status. CONCLUSIONS: These findings suggest that iron deficiency may play a role in low-grade chronic inflammation among relatively healthy older adults. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40520-021-01955-3. Springer International Publishing 2021-09-17 2022 /pmc/articles/PMC8894209/ /pubmed/34533774 http://dx.doi.org/10.1007/s40520-021-01955-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Wieczorek, Maud Schwarz, Franziska Sadlon, Angélique Abderhalden, Lauren A. de Godoi Rezende Costa Molino, Caroline Spahn, Donat R. Schaer, Dominik J. Orav, E. John Egli, Andreas Bischoff-Ferrari, Heike A. Iron deficiency and biomarkers of inflammation: a 3-year prospective analysis of the DO-HEALTH trial |
title | Iron deficiency and biomarkers of inflammation: a 3-year prospective analysis of the DO-HEALTH trial |
title_full | Iron deficiency and biomarkers of inflammation: a 3-year prospective analysis of the DO-HEALTH trial |
title_fullStr | Iron deficiency and biomarkers of inflammation: a 3-year prospective analysis of the DO-HEALTH trial |
title_full_unstemmed | Iron deficiency and biomarkers of inflammation: a 3-year prospective analysis of the DO-HEALTH trial |
title_short | Iron deficiency and biomarkers of inflammation: a 3-year prospective analysis of the DO-HEALTH trial |
title_sort | iron deficiency and biomarkers of inflammation: a 3-year prospective analysis of the do-health trial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894209/ https://www.ncbi.nlm.nih.gov/pubmed/34533774 http://dx.doi.org/10.1007/s40520-021-01955-3 |
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