PD-1 and TIGIT blockade differentially affect tumour cell survival under hypoxia and glucose deprived conditions in oesophageal adenocarcinoma; implications for overcoming resistance to PD-1 blockade in hypoxic tumours

Recent studies have demontrated that immune checkpoint receptors are expressed on the surface of oesophageal adenocarcinoma (OAC) cells and might confer a survival advantage. This study explores the role of PD-1 and TIGIT signalling in OAC cells in either promoting or inhibiting the survival of OAC...

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Detalles Bibliográficos
Autores principales: Davern, Maria, Fitzgerald, Marie-Claire, Buckley, Croí E., Heeran, Aisling B., Donlon, Noel E., McGrath, Jason, O’ Connell, Fiona, Deshpande, Malvika R., Hayes, Conall, MacDonald, Jamie, Sheppard, Andrew D., Reynolds, John V., Maher, Stephen G., Lynam-Lennon, Niamh, Murphy, Brona, Lysaght, Joanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894275/
https://www.ncbi.nlm.nih.gov/pubmed/35245832
http://dx.doi.org/10.1016/j.tranon.2022.101381

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