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Anti-inflammatory effects of an autologous gold-based serum therapy in osteoarthritis patients
Osteoarthritis (OA) involves activation and recruitment of immune cells to affected joints, including the production of pro-inflammatory cytokines. Here, a gold-based autologous serum therapy is investigated for its effect on peripheral blood cell composition and cytokine levels in OA patients. From...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894375/ https://www.ncbi.nlm.nih.gov/pubmed/35241691 http://dx.doi.org/10.1038/s41598-022-07187-3 |
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author | Feldt, Jessica Donaubauer, Anna-Jasmina Welss, Jessica Schneider, Ulrich Gaipl, Udo S. Paulsen, Friedrich |
author_facet | Feldt, Jessica Donaubauer, Anna-Jasmina Welss, Jessica Schneider, Ulrich Gaipl, Udo S. Paulsen, Friedrich |
author_sort | Feldt, Jessica |
collection | PubMed |
description | Osteoarthritis (OA) involves activation and recruitment of immune cells to affected joints, including the production of pro-inflammatory cytokines. Here, a gold-based autologous serum therapy is investigated for its effect on peripheral blood cell composition and cytokine levels in OA patients. From six OA patients serum and blood samples were collected before and after second therapy treatment for analysis of peripheral blood cell composition as well as cytokine levels compared to control samples. This therapy significantly downregulates CD4(+) T cells and B cells in OA patients after second treatment compared to healthy controls. Monocytes are significantly upregulated in patients after second treatment Serum IL-9 and TNF-α levels are downregulated in patients after second treatment compared to healthy control serum. The activation status of immune cells was modulated after therapy in patients. Anti-inflammatory effects of the peripheral blood cell composition in OA patients can be seen after therapy treatment. After two treatments IL-9 and TNF-α are significantly downregulated in patient serum. Here, primary data of a new autologous therapy for OA treatment and its modulatory effects on cytokines are presented. |
format | Online Article Text |
id | pubmed-8894375 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-88943752022-03-07 Anti-inflammatory effects of an autologous gold-based serum therapy in osteoarthritis patients Feldt, Jessica Donaubauer, Anna-Jasmina Welss, Jessica Schneider, Ulrich Gaipl, Udo S. Paulsen, Friedrich Sci Rep Article Osteoarthritis (OA) involves activation and recruitment of immune cells to affected joints, including the production of pro-inflammatory cytokines. Here, a gold-based autologous serum therapy is investigated for its effect on peripheral blood cell composition and cytokine levels in OA patients. From six OA patients serum and blood samples were collected before and after second therapy treatment for analysis of peripheral blood cell composition as well as cytokine levels compared to control samples. This therapy significantly downregulates CD4(+) T cells and B cells in OA patients after second treatment compared to healthy controls. Monocytes are significantly upregulated in patients after second treatment Serum IL-9 and TNF-α levels are downregulated in patients after second treatment compared to healthy control serum. The activation status of immune cells was modulated after therapy in patients. Anti-inflammatory effects of the peripheral blood cell composition in OA patients can be seen after therapy treatment. After two treatments IL-9 and TNF-α are significantly downregulated in patient serum. Here, primary data of a new autologous therapy for OA treatment and its modulatory effects on cytokines are presented. Nature Publishing Group UK 2022-03-03 /pmc/articles/PMC8894375/ /pubmed/35241691 http://dx.doi.org/10.1038/s41598-022-07187-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Feldt, Jessica Donaubauer, Anna-Jasmina Welss, Jessica Schneider, Ulrich Gaipl, Udo S. Paulsen, Friedrich Anti-inflammatory effects of an autologous gold-based serum therapy in osteoarthritis patients |
title | Anti-inflammatory effects of an autologous gold-based serum therapy in osteoarthritis patients |
title_full | Anti-inflammatory effects of an autologous gold-based serum therapy in osteoarthritis patients |
title_fullStr | Anti-inflammatory effects of an autologous gold-based serum therapy in osteoarthritis patients |
title_full_unstemmed | Anti-inflammatory effects of an autologous gold-based serum therapy in osteoarthritis patients |
title_short | Anti-inflammatory effects of an autologous gold-based serum therapy in osteoarthritis patients |
title_sort | anti-inflammatory effects of an autologous gold-based serum therapy in osteoarthritis patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894375/ https://www.ncbi.nlm.nih.gov/pubmed/35241691 http://dx.doi.org/10.1038/s41598-022-07187-3 |
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