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A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing

The intrinsically unstructured C9ORF78 protein was detected in spliceosomes but its role in splicing is presently unclear. We find that C9ORF78 tightly interacts with the spliceosome remodeling factor, BRR2, in vitro. Affinity purification/mass spectrometry and RNA UV-crosslinking analyses identify...

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Detalles Bibliográficos
Autores principales:	Bergfort, Alexandra, Preußner, Marco, Kuropka, Benno, Ilik, İbrahim Avşar, Hilal, Tarek, Weber, Gert, Freund, Christian, Aktaş, Tuğçe, Heyd, Florian, Wahl, Markus C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894380/ https://www.ncbi.nlm.nih.gov/pubmed/35241646 http://dx.doi.org/10.1038/s41467-022-28754-2

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