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Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis

Low back pain (LBP) is a major musculoskeletal disorder and the socioeconomic problem with a high prevalence that mainly involves intervertebral disc (IVD) degeneration, characterized by progressive nucleus pulposus (NP) cell death and the development of an inflammatory microenvironment in NP tissue...

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Detalles Bibliográficos
Autores principales:	Zhang, Weifeng, Li, Gaocai, Luo, Rongjin, Lei, Jie, Song, Yu, Wang, Bingjin, Ma, Liang, Liao, Zhiwei, Ke, Wencan, Liu, Hui, Hua, Wenbin, Zhao, Kangcheng, Feng, Xiaobo, Wu, Xinghuo, Zhang, Yukun, Wang, Kun, Yang, Cao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894389/ https://www.ncbi.nlm.nih.gov/pubmed/35145201 http://dx.doi.org/10.1038/s12276-022-00729-9

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