Scaling SARS-CoV-2 wastewater concentrations to population estimates of infection

Monitoring the progression of SARS-CoV-2 outbreaks requires accurate estimation of the unobservable fraction of the population infected over time in addition to the observed numbers of COVID-19 cases, as the latter present a distorted view of the pandemic due to changes in test frequency and coverag...

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Autores principales: Kaplan, Edward H., Zulli, Alessandro, Sanchez, Marcela, Peccia, Jordan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894397/
https://www.ncbi.nlm.nih.gov/pubmed/35241744
http://dx.doi.org/10.1038/s41598-022-07523-7
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author Kaplan, Edward H.
Zulli, Alessandro
Sanchez, Marcela
Peccia, Jordan
author_facet Kaplan, Edward H.
Zulli, Alessandro
Sanchez, Marcela
Peccia, Jordan
author_sort Kaplan, Edward H.
collection PubMed
description Monitoring the progression of SARS-CoV-2 outbreaks requires accurate estimation of the unobservable fraction of the population infected over time in addition to the observed numbers of COVID-19 cases, as the latter present a distorted view of the pandemic due to changes in test frequency and coverage over time. The objective of this report is to describe and illustrate an approach that produces representative estimates of the unobservable cumulative incidence of infection by scaling the daily concentrations of SARS-CoV-2 RNA in wastewater from the consistent population contribution of fecal material to the sewage collection system.
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spelling pubmed-88943972022-03-07 Scaling SARS-CoV-2 wastewater concentrations to population estimates of infection Kaplan, Edward H. Zulli, Alessandro Sanchez, Marcela Peccia, Jordan Sci Rep Article Monitoring the progression of SARS-CoV-2 outbreaks requires accurate estimation of the unobservable fraction of the population infected over time in addition to the observed numbers of COVID-19 cases, as the latter present a distorted view of the pandemic due to changes in test frequency and coverage over time. The objective of this report is to describe and illustrate an approach that produces representative estimates of the unobservable cumulative incidence of infection by scaling the daily concentrations of SARS-CoV-2 RNA in wastewater from the consistent population contribution of fecal material to the sewage collection system. Nature Publishing Group UK 2022-03-03 /pmc/articles/PMC8894397/ /pubmed/35241744 http://dx.doi.org/10.1038/s41598-022-07523-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kaplan, Edward H.
Zulli, Alessandro
Sanchez, Marcela
Peccia, Jordan
Scaling SARS-CoV-2 wastewater concentrations to population estimates of infection
title Scaling SARS-CoV-2 wastewater concentrations to population estimates of infection
title_full Scaling SARS-CoV-2 wastewater concentrations to population estimates of infection
title_fullStr Scaling SARS-CoV-2 wastewater concentrations to population estimates of infection
title_full_unstemmed Scaling SARS-CoV-2 wastewater concentrations to population estimates of infection
title_short Scaling SARS-CoV-2 wastewater concentrations to population estimates of infection
title_sort scaling sars-cov-2 wastewater concentrations to population estimates of infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894397/
https://www.ncbi.nlm.nih.gov/pubmed/35241744
http://dx.doi.org/10.1038/s41598-022-07523-7
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