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miR-146a impedes the anti-aging effect of AMPK via NAMPT suppression and NAD(+)/SIRT inactivation

Nicotinamide adenine dinucleotide (NAD(+)) is indispensable for the anti-aging activity of the sirtuin (SIRT) family enzymes. AMP-activated protein kinase (AMPK) upregulates NAD(+) synthesis and SIRT activity in a nicotinamide phosphoribosyltransferase (NAMPT)-dependent manner. However, the molecula...

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Detalles Bibliográficos
Autores principales:	Gong, Hui, Chen, Honghan, Xiao, Peng, Huang, Ning, Han, Xiaojuan, Zhang, Jian, Yang, Yu, Li, Tiepeng, Zhao, Tingting, Tai, Haoran, Xu, Weitong, Zhang, Gongchang, Gong, Chuhui, Yang, Ming, Tang, Xiaoqiang, Xiao, Hengyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894495/ https://www.ncbi.nlm.nih.gov/pubmed/35241643 http://dx.doi.org/10.1038/s41392-022-00886-3

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