Concerted BAG3 and SIRPα blockade impairs pancreatic tumor growth

The BAG3- and SIRPα- mediated pathways trigger distinct cellular targets and signaling mechanisms in pancreatic cancer microenvironment. To explore their functional connection, we investigated the effects of their combined blockade on cancer growth in orthotopic allografts of pancreatic cancer mt4–2...

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Detalles Bibliográficos
Autores principales: De Marco, Margot, Gauttier, Vanessa, Pengam, Sabrina, Mary, Caroline, Ranieri, Bianca, Basile, Anna, Festa, Michela, Falco, Antonia, Reppucci, Francesca, Cammarota, Anna Lisa, Acernese, Fausto, De Laurenzi, Vincenzo, Sala, Gianluca, Brongo, Sergio, Miyasaka, Masayuki, Shalapour, Shabnam, Vanhove, Bernard, Poirier, Nicolas, Iaccarino, Roberta, Karin, Michael, Turco, Maria Caterina, Rosati, Alessandra, Marzullo, Liberato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894496/
https://www.ncbi.nlm.nih.gov/pubmed/35241649
http://dx.doi.org/10.1038/s41420-022-00817-9

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