Azepanodipterocarpol is potential candidate for inhibits influenza H1N1 type among other lupane, oleanane, and dammarane A-ring amino-triterpenoids

A series of lupane-, oleanane- and dammarane-based triterpenoids with 3β-amino, A-ring azepano- and 3,4-seco-fragments has been synthesized and evaluated for antiviral activity against influenza A(H1N1) virus. It was found that azepanodipterocarpol 8 and 3β-amino-28-oxoallobetulin 11 showed antivira...

Descripción completa

Detalles Bibliográficos
Autores principales: Smirnova, Irina, Petrova, Anastasiya, Lobov, Alexander, Minnibaeva, El’za, Phoung, Thao Tran Thi, Van, Loc Tran, Khine, Myint Myint, Esaulkova, Iana, Slita, Alexander, Zarubaev, Vladimir, Kazakova, Oxana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894567/
https://www.ncbi.nlm.nih.gov/pubmed/35246615
http://dx.doi.org/10.1038/s41429-022-00514-w
_version_ 1784662702311866368
author Smirnova, Irina
Petrova, Anastasiya
Lobov, Alexander
Minnibaeva, El’za
Phoung, Thao Tran Thi
Van, Loc Tran
Khine, Myint Myint
Esaulkova, Iana
Slita, Alexander
Zarubaev, Vladimir
Kazakova, Oxana
author_facet Smirnova, Irina
Petrova, Anastasiya
Lobov, Alexander
Minnibaeva, El’za
Phoung, Thao Tran Thi
Van, Loc Tran
Khine, Myint Myint
Esaulkova, Iana
Slita, Alexander
Zarubaev, Vladimir
Kazakova, Oxana
author_sort Smirnova, Irina
collection PubMed
description A series of lupane-, oleanane- and dammarane-based triterpenoids with 3β-amino, A-ring azepano- and 3,4-seco-fragments has been synthesized and evaluated for antiviral activity against influenza A(H1N1) virus. It was found that azepanodipterocarpol 8 and 3β-amino-28-oxoallobetulin 11 showed antiviral activity with IC(50) 1.1 and 2.6 μg ml(−1), and selectivity index of 19 and 10, respectively.
format Online
Article
Text
id pubmed-8894567
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-88945672022-03-04 Azepanodipterocarpol is potential candidate for inhibits influenza H1N1 type among other lupane, oleanane, and dammarane A-ring amino-triterpenoids Smirnova, Irina Petrova, Anastasiya Lobov, Alexander Minnibaeva, El’za Phoung, Thao Tran Thi Van, Loc Tran Khine, Myint Myint Esaulkova, Iana Slita, Alexander Zarubaev, Vladimir Kazakova, Oxana J Antibiot (Tokyo) Article A series of lupane-, oleanane- and dammarane-based triterpenoids with 3β-amino, A-ring azepano- and 3,4-seco-fragments has been synthesized and evaluated for antiviral activity against influenza A(H1N1) virus. It was found that azepanodipterocarpol 8 and 3β-amino-28-oxoallobetulin 11 showed antiviral activity with IC(50) 1.1 and 2.6 μg ml(−1), and selectivity index of 19 and 10, respectively. Nature Publishing Group UK 2022-03-04 2022 /pmc/articles/PMC8894567/ /pubmed/35246615 http://dx.doi.org/10.1038/s41429-022-00514-w Text en © The Author(s), under exclusive licence to the Japan Antibiotics Research Association 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Smirnova, Irina
Petrova, Anastasiya
Lobov, Alexander
Minnibaeva, El’za
Phoung, Thao Tran Thi
Van, Loc Tran
Khine, Myint Myint
Esaulkova, Iana
Slita, Alexander
Zarubaev, Vladimir
Kazakova, Oxana
Azepanodipterocarpol is potential candidate for inhibits influenza H1N1 type among other lupane, oleanane, and dammarane A-ring amino-triterpenoids
title Azepanodipterocarpol is potential candidate for inhibits influenza H1N1 type among other lupane, oleanane, and dammarane A-ring amino-triterpenoids
title_full Azepanodipterocarpol is potential candidate for inhibits influenza H1N1 type among other lupane, oleanane, and dammarane A-ring amino-triterpenoids
title_fullStr Azepanodipterocarpol is potential candidate for inhibits influenza H1N1 type among other lupane, oleanane, and dammarane A-ring amino-triterpenoids
title_full_unstemmed Azepanodipterocarpol is potential candidate for inhibits influenza H1N1 type among other lupane, oleanane, and dammarane A-ring amino-triterpenoids
title_short Azepanodipterocarpol is potential candidate for inhibits influenza H1N1 type among other lupane, oleanane, and dammarane A-ring amino-triterpenoids
title_sort azepanodipterocarpol is potential candidate for inhibits influenza h1n1 type among other lupane, oleanane, and dammarane a-ring amino-triterpenoids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894567/
https://www.ncbi.nlm.nih.gov/pubmed/35246615
http://dx.doi.org/10.1038/s41429-022-00514-w
work_keys_str_mv AT smirnovairina azepanodipterocarpolispotentialcandidateforinhibitsinfluenzah1n1typeamongotherlupaneoleananeanddammaranearingaminotriterpenoids
AT petrovaanastasiya azepanodipterocarpolispotentialcandidateforinhibitsinfluenzah1n1typeamongotherlupaneoleananeanddammaranearingaminotriterpenoids
AT lobovalexander azepanodipterocarpolispotentialcandidateforinhibitsinfluenzah1n1typeamongotherlupaneoleananeanddammaranearingaminotriterpenoids
AT minnibaevaelza azepanodipterocarpolispotentialcandidateforinhibitsinfluenzah1n1typeamongotherlupaneoleananeanddammaranearingaminotriterpenoids
AT phoungthaotranthi azepanodipterocarpolispotentialcandidateforinhibitsinfluenzah1n1typeamongotherlupaneoleananeanddammaranearingaminotriterpenoids
AT vanloctran azepanodipterocarpolispotentialcandidateforinhibitsinfluenzah1n1typeamongotherlupaneoleananeanddammaranearingaminotriterpenoids
AT khinemyintmyint azepanodipterocarpolispotentialcandidateforinhibitsinfluenzah1n1typeamongotherlupaneoleananeanddammaranearingaminotriterpenoids
AT esaulkovaiana azepanodipterocarpolispotentialcandidateforinhibitsinfluenzah1n1typeamongotherlupaneoleananeanddammaranearingaminotriterpenoids
AT slitaalexander azepanodipterocarpolispotentialcandidateforinhibitsinfluenzah1n1typeamongotherlupaneoleananeanddammaranearingaminotriterpenoids
AT zarubaevvladimir azepanodipterocarpolispotentialcandidateforinhibitsinfluenzah1n1typeamongotherlupaneoleananeanddammaranearingaminotriterpenoids
AT kazakovaoxana azepanodipterocarpolispotentialcandidateforinhibitsinfluenzah1n1typeamongotherlupaneoleananeanddammaranearingaminotriterpenoids

Ejemplares similares