Cargando…

Single-Cell Transcriptome Reveals the Metabolic and Clinical Features of a Highly Malignant Cell Subpopulation in Pancreatic Ductal Adenocarcinoma

Background: Pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with a high mortality rate. PDAC exhibits significant heterogeneity as well as alterations in metabolic pathways that are associated with its malignant progression. In this study, we explored the metabolic and clinical features...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fang, Yangyang, Pei, Shunjie, Huang, Kaizhao, Xu, Feng, Xiang, Guangxin, Lan, Linhua, Zheng, Xiaoqun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894596/ https://www.ncbi.nlm.nih.gov/pubmed/35252177 http://dx.doi.org/10.3389/fcell.2022.798165

Ejemplares similares

The Crosstalk Between Malignant Cells and Tumor-Promoting Immune Cells Relevant to Immunotherapy in Pancreatic Ductal Adenocarcinoma
por: Liu, Xuefei, et al.
Publicado: (2022)

Editorial: Translational Insights Into Pancreatic Ductal Adenocarcinoma
por: Bijlsma, Maarten F., et al.
Publicado: (2022)

Single-cell transcriptome profiling reveals enriched memory T-cell subpopulations in hypertension
por: Wang, Xiaoqi, et al.
Publicado: (2023)

Pancreatic Ductal Adenocarcinoma: Preclinical in vitro and ex vivo Models
por: Gündel, Beate, et al.
Publicado: (2021)

KRAS mutation: The booster of pancreatic ductal adenocarcinoma transformation and progression
por: Zhang, Zining, et al.
Publicado: (2023)

METTL16 predicts a favorable outcome and primes antitumor immunity in pancreatic ductal adenocarcinoma
por: Lu, Liting, et al.
Publicado: (2022)

GATA4 Regulates Inflammation-Driven Pancreatic Ductal Adenocarcinoma Progression
por: Jiang, Weiliang, et al.
Publicado: (2021)

Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: Origin, Polarization, Function, and Reprogramming
por: Yang, Sen, et al.
Publicado: (2021)

Retraction: GATA4 regulates inflammation-driven pancreatic ductal adenocarcinoma progression
Publicado: (2023)

Impact of Extracellular pH on Apoptotic and Non-Apoptotic TRAIL-Induced Signaling in Pancreatic Ductal Adenocarcinoma Cells
por: Hagelund, Sofie, et al.
Publicado: (2022)

Type 1 T Helper Cell-Based Molecular Subtypes and Signature Are Associated with Clinical Outcome in Pancreatic Ductal Adenocarcinoma
por: Wei, Ran, et al.
Publicado: (2022)

Mitofusin 1-Mediated Redistribution of Mitochondrial Antiviral Signaling Protein Promotes Type 1 Interferon Response in Human Cytomegalovirus Infection
por: Huang, Kaizhao, et al.
Publicado: (2023)

Proteome-Wide Alterations of Asymmetric Arginine Dimethylation Associated With Pancreatic Ductal Adenocarcinoma Pathogenesis
por: Wei, Meijin, et al.
Publicado: (2020)

DNA Damage Repair Deficiency in Pancreatic Ductal Adenocarcinoma: Preclinical Models and Clinical Perspectives
por: Stoof, Jojanneke, et al.
Publicado: (2021)

Autophagy Blockage Reduces the Incidence of Pancreatic Ductal Adenocarcinoma in the Context of Mutant Trp53
por: Mainz, Laura, et al.
Publicado: (2022)

An EMT-Related Gene Signature for Predicting Response to Adjuvant Chemotherapy in Pancreatic Ductal Adenocarcinoma
por: Feng, Zengyu, et al.
Publicado: (2021)

Microfluidic Platforms for High-Throughput Pancreatic Ductal Adenocarcinoma Organoid Culture and Drug Screening
por: Geyer, Marlene, et al.
Publicado: (2021)

Early Diagnosis of Pancreatic Ductal Adenocarcinoma by Combining Relative Expression Orderings With Machine-Learning Method
por: Zhang, Zi-Mei, et al.
Publicado: (2020)

The Intricate Crosstalk Between Insulin and Pancreatic Ductal Adenocarcinoma: A Review From Clinical to Molecular
por: Deng, Junyuan, et al.
Publicado: (2022)

Overexpression of MUC1 Induces Non-Canonical TGF-β Signaling in Pancreatic Ductal Adenocarcinoma
por: Bose, Mukulika, et al.
Publicado: (2022)

The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma
por: Krah, Nathan M, et al.
Publicado: (2015)

NUCB1 Suppresses Growth and Shows Additive Effects With Gemcitabine in Pancreatic Ductal Adenocarcinoma via the Unfolded Protein Response
por: Hua, Yong-Qiang, et al.
Publicado: (2021)

Subpopulations of cancer-associated fibroblasts link the prognosis and metabolic features of pancreatic ductal adenocarcinoma
por: Hu, Beiyuan, et al.
Publicado: (2022)

RNA m(6)A Demethylase ALKBH5 Protects Against Pancreatic Ductal Adenocarcinoma via Targeting Regulators of Iron Metabolism
por: Huang, Rui, et al.
Publicado: (2021)

Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells
por: Lee, Jonghyeob, et al.
Publicado: (2013)

Heterogeneous Pancreatic Stellate Cells Are Powerful Contributors to the Malignant Progression of Pancreatic Cancer
por: Zhang, Zhilin, et al.
Publicado: (2021)

Glycine Promotes the Survival of a Subpopulation of Neural Stem Cells
por: Bekri, Abdelhamid, et al.
Publicado: (2018)

Tendon Stem/Progenitor Cell Subpopulations and Their Implications in Tendon Biology
por: Huang, Zizhan, et al.
Publicado: (2021)

Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree
por: Hendley, Audrey M, et al.
Publicado: (2021)

Circulating Tumor Cell Subpopulations Predict Treatment Outcome in Pancreatic Ductal Adenocarcinoma (PDAC) Patients
por: Freed, Ian M., et al.
Publicado: (2023)

A Novel DNA Replication-Related Signature Predicting Recurrence After R0 Resection of Pancreatic Ductal Adenocarcinoma: Prognostic Value and Clinical Implications
por: Feng, Zengyu, et al.
Publicado: (2021)

A pancreatic ductal adenocarcinoma subpopulation is sensitive to FK866, an inhibitor of NAMPT
por: Barraud, Marine, et al.
Publicado: (2016)

Single-cell RNA sequencing reveals cell subpopulations in the tumor microenvironment contributing to hepatocellular carcinoma
por: Gao, Jiamin, et al.
Publicado: (2023)

Nuclear GSK-3β and Oncogenic KRas Lead to the Retention of Pancreatic Ductal Progenitor Cells Phenotypically Similar to Those Seen in IPMN
por: Ding, Li, et al.
Publicado: (2022)

The tendon interfascicular basement membrane provides a vascular niche for CD146+ cell subpopulations
por: Marr, Neil, et al.
Publicado: (2023)

Identification of a Novel Subpopulation of Tumor-Initiating Cells from Gemcitabine-Resistant Pancreatic Ductal Adenocarcinoma Patients
por: Shimizu, Kazuya, et al.
Publicado: (2013)

SLC1A5 Prefers to Play as an Accomplice Rather Than an Opponent in Pancreatic Adenocarcinoma
por: Xu, Fangshi, et al.
Publicado: (2022)

Transcriptome Reprogramming of CD11b(+) Bone Marrow Cells by Pancreatic Cancer Extracellular Vesicles
por: Maia, Joana, et al.
Publicado: (2020)

Integrating single cell transcriptomics and volume electron microscopy confirms the presence of pancreatic acinar-like cells in sea urchins
por: Paganos, Periklis, et al.
Publicado: (2022)

Suppression of Endothelial Cell FAK Expression Reduces Pancreatic Ductal Adenocarcinoma Metastasis after Gemcitabine Treatment
por: Roy-Luzarraga, Marina, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fks8jp12t3tsjss8572apvd0gu