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Predictive role of C-reactive protein in sudden death: a meta-analysis of prospective studies

OBJECTIVE: C-reactive protein (CRP) is a powerful predictor of and risk factor for cardiovascular disease. However, the relationship between CRP and sudden death (SD) is controversial. Therefore, we performed a meta-analysis to evaluate the association between CRP and SD. METHODS: We conducted a com...

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Autores principales: Zhou, Ruhua, Xu, Jingjing, Luan, Jiaochen, Wang, Weiyun, Tang, Xinzhi, Huang, Yanling, Su, Ziwen, Yang, Lei, Gu, Zejuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894975/
https://www.ncbi.nlm.nih.gov/pubmed/35225715
http://dx.doi.org/10.1177/03000605221079547
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author Zhou, Ruhua
Xu, Jingjing
Luan, Jiaochen
Wang, Weiyun
Tang, Xinzhi
Huang, Yanling
Su, Ziwen
Yang, Lei
Gu, Zejuan
author_facet Zhou, Ruhua
Xu, Jingjing
Luan, Jiaochen
Wang, Weiyun
Tang, Xinzhi
Huang, Yanling
Su, Ziwen
Yang, Lei
Gu, Zejuan
author_sort Zhou, Ruhua
collection PubMed
description OBJECTIVE: C-reactive protein (CRP) is a powerful predictor of and risk factor for cardiovascular disease. However, the relationship between CRP and sudden death (SD) is controversial. Therefore, we performed a meta-analysis to evaluate the association between CRP and SD. METHODS: We conducted a comprehensive search of the databases of PubMed, Web of Science, Embase, Cochrane Library, Wanfang, CNKI, China Biology Medicine disc, and Weipu. Two researchers independently screened the literature, extracted data, and evaluated the data quality. The overall effect size was meta-analyzed using Stata software version 12.0 (StataCorp, College Station, TX, USA). RESULTS: Twelve prospective studies involving 36,646 patients were included in the present meta-analysis. The data revealed that patients with higher CRP concentrations had a greater risk of SD (hazard ratio, 1.19; 95% confidence interval, 1.09–1.29). When the hazard ratio of SD was calculated by multivariate analysis of nine studies, CRP was confirmed to be an independent predictive factor for SD (hazard ratio, 1.05; 95% confidence interval, 1.03–1.07). CONCLUSIONS: This meta-analysis confirmed that CRP is an independent predictor of SD. These results support the recommendation of recording the CRP concentration for risk assessment of SD in clinical practice.
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spelling pubmed-88949752022-03-05 Predictive role of C-reactive protein in sudden death: a meta-analysis of prospective studies Zhou, Ruhua Xu, Jingjing Luan, Jiaochen Wang, Weiyun Tang, Xinzhi Huang, Yanling Su, Ziwen Yang, Lei Gu, Zejuan J Int Med Res Meta Analysis OBJECTIVE: C-reactive protein (CRP) is a powerful predictor of and risk factor for cardiovascular disease. However, the relationship between CRP and sudden death (SD) is controversial. Therefore, we performed a meta-analysis to evaluate the association between CRP and SD. METHODS: We conducted a comprehensive search of the databases of PubMed, Web of Science, Embase, Cochrane Library, Wanfang, CNKI, China Biology Medicine disc, and Weipu. Two researchers independently screened the literature, extracted data, and evaluated the data quality. The overall effect size was meta-analyzed using Stata software version 12.0 (StataCorp, College Station, TX, USA). RESULTS: Twelve prospective studies involving 36,646 patients were included in the present meta-analysis. The data revealed that patients with higher CRP concentrations had a greater risk of SD (hazard ratio, 1.19; 95% confidence interval, 1.09–1.29). When the hazard ratio of SD was calculated by multivariate analysis of nine studies, CRP was confirmed to be an independent predictive factor for SD (hazard ratio, 1.05; 95% confidence interval, 1.03–1.07). CONCLUSIONS: This meta-analysis confirmed that CRP is an independent predictor of SD. These results support the recommendation of recording the CRP concentration for risk assessment of SD in clinical practice. SAGE Publications 2022-02-28 /pmc/articles/PMC8894975/ /pubmed/35225715 http://dx.doi.org/10.1177/03000605221079547 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Meta Analysis
Zhou, Ruhua
Xu, Jingjing
Luan, Jiaochen
Wang, Weiyun
Tang, Xinzhi
Huang, Yanling
Su, Ziwen
Yang, Lei
Gu, Zejuan
Predictive role of C-reactive protein in sudden death: a meta-analysis of prospective studies
title Predictive role of C-reactive protein in sudden death: a meta-analysis of prospective studies
title_full Predictive role of C-reactive protein in sudden death: a meta-analysis of prospective studies
title_fullStr Predictive role of C-reactive protein in sudden death: a meta-analysis of prospective studies
title_full_unstemmed Predictive role of C-reactive protein in sudden death: a meta-analysis of prospective studies
title_short Predictive role of C-reactive protein in sudden death: a meta-analysis of prospective studies
title_sort predictive role of c-reactive protein in sudden death: a meta-analysis of prospective studies
topic Meta Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894975/
https://www.ncbi.nlm.nih.gov/pubmed/35225715
http://dx.doi.org/10.1177/03000605221079547
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