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Crystal structures of PigF, an O-methyltransferase involved in the prodigiosin synthetic pathway, reveal an induced-fit substrate-recognition mechanism

Prodigiosin, a red linear tripyrrole pigment, is a typical secondary metabolite with numerous biological functions, such as anticancer, antibacterial and immunosuppressant activities, and is synthesized through a bifurcated biosynthesis pathway from 4-methoxy-2,2′-bipyrrole-5-carbaldehyde (MBC) and...

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Detalles Bibliográficos
Autores principales: Qiu, Shenshen, Xu, Dongqing, Xu, Mengxue, Zhou, Huan, Sun, Ning, Zhang, Li, Zhao, Mengmeng, He, Jianhua, Ran, Tingting, Sun, Bo, Wang, Weiwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895007/
https://www.ncbi.nlm.nih.gov/pubmed/35371495
http://dx.doi.org/10.1107/S2052252521011696