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Bortezomib‐Encapsulated Dual Responsive Copolymeric Nanoparticles for Gallbladder Cancer Targeted Therapy
Gallbladder cancer (GBC) is a rare but the most malignant type of biliary tract tumor. It is usually diagnosed at an advanced stage and conventional treatments are unsatisfactory. As a proteasome inhibitor, bortezomib (BTZ) exhibits excellent antitumor ability in GBC. However, the long‐term treatmen...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895115/ https://www.ncbi.nlm.nih.gov/pubmed/35068071 http://dx.doi.org/10.1002/advs.202103895 |
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author | Chen, Mingyu Juengpanich, Sarun Li, Shijie Topatana, Win Lu, Ziyi Zheng, Qiang Cao, Jiasheng Hu, Jiahao Chan, Esther Hou, Lidan Chen, Jiang Chen, Fang Liu, Yu Jiansirisomboon, Sukanda Gu, Zhen Tongpeng, Suparat Cai, Xiujun |
author_facet | Chen, Mingyu Juengpanich, Sarun Li, Shijie Topatana, Win Lu, Ziyi Zheng, Qiang Cao, Jiasheng Hu, Jiahao Chan, Esther Hou, Lidan Chen, Jiang Chen, Fang Liu, Yu Jiansirisomboon, Sukanda Gu, Zhen Tongpeng, Suparat Cai, Xiujun |
author_sort | Chen, Mingyu |
collection | PubMed |
description | Gallbladder cancer (GBC) is a rare but the most malignant type of biliary tract tumor. It is usually diagnosed at an advanced stage and conventional treatments are unsatisfactory. As a proteasome inhibitor, bortezomib (BTZ) exhibits excellent antitumor ability in GBC. However, the long‐term treatment efficacy is limited by its resistance, poor stability, and high toxicity. Herein, BTZ‐encapsulated pH‐responsive copolymeric nanoparticles with estrone (ES‐NP((BTZ; Ce6))) for GBC‐specific targeted therapy is reported. Due to the high estrogen receptor expression in GBC, ES‐NP((BTZ; Ce6)) can rapidly enter the cells and accumulate near the nucleus via ES‐mediated endocytosis. Under acidic tumor microenvironment (TME) and 808 nm laser irradiation, BTZ is released and ROS is generated by Ce6 to destroy the “bounce‐back” response pathway proteins, such as DDI2 and p97, which can effectively inhibit proteasomes and increase apoptosis. Compared to the traditional treatment using BTZ monotherapy, ES‐NP((BTZ; Ce6)) can significantly impede disease progression at lower BTZ concentrations and improve its resistance. Moreover, ES‐NP((BTZ; Ce6)) demonstrates similar antitumor abilities in patient‐derived xenograft animal models and five other types of solid tumor cells, revealing its potential as a broad‐spectrum antitumor formulation. |
format | Online Article Text |
id | pubmed-8895115 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88951152022-03-10 Bortezomib‐Encapsulated Dual Responsive Copolymeric Nanoparticles for Gallbladder Cancer Targeted Therapy Chen, Mingyu Juengpanich, Sarun Li, Shijie Topatana, Win Lu, Ziyi Zheng, Qiang Cao, Jiasheng Hu, Jiahao Chan, Esther Hou, Lidan Chen, Jiang Chen, Fang Liu, Yu Jiansirisomboon, Sukanda Gu, Zhen Tongpeng, Suparat Cai, Xiujun Adv Sci (Weinh) Research Articles Gallbladder cancer (GBC) is a rare but the most malignant type of biliary tract tumor. It is usually diagnosed at an advanced stage and conventional treatments are unsatisfactory. As a proteasome inhibitor, bortezomib (BTZ) exhibits excellent antitumor ability in GBC. However, the long‐term treatment efficacy is limited by its resistance, poor stability, and high toxicity. Herein, BTZ‐encapsulated pH‐responsive copolymeric nanoparticles with estrone (ES‐NP((BTZ; Ce6))) for GBC‐specific targeted therapy is reported. Due to the high estrogen receptor expression in GBC, ES‐NP((BTZ; Ce6)) can rapidly enter the cells and accumulate near the nucleus via ES‐mediated endocytosis. Under acidic tumor microenvironment (TME) and 808 nm laser irradiation, BTZ is released and ROS is generated by Ce6 to destroy the “bounce‐back” response pathway proteins, such as DDI2 and p97, which can effectively inhibit proteasomes and increase apoptosis. Compared to the traditional treatment using BTZ monotherapy, ES‐NP((BTZ; Ce6)) can significantly impede disease progression at lower BTZ concentrations and improve its resistance. Moreover, ES‐NP((BTZ; Ce6)) demonstrates similar antitumor abilities in patient‐derived xenograft animal models and five other types of solid tumor cells, revealing its potential as a broad‐spectrum antitumor formulation. John Wiley and Sons Inc. 2022-01-23 /pmc/articles/PMC8895115/ /pubmed/35068071 http://dx.doi.org/10.1002/advs.202103895 Text en © 2022 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Chen, Mingyu Juengpanich, Sarun Li, Shijie Topatana, Win Lu, Ziyi Zheng, Qiang Cao, Jiasheng Hu, Jiahao Chan, Esther Hou, Lidan Chen, Jiang Chen, Fang Liu, Yu Jiansirisomboon, Sukanda Gu, Zhen Tongpeng, Suparat Cai, Xiujun Bortezomib‐Encapsulated Dual Responsive Copolymeric Nanoparticles for Gallbladder Cancer Targeted Therapy |
title | Bortezomib‐Encapsulated Dual Responsive Copolymeric Nanoparticles for Gallbladder Cancer Targeted Therapy |
title_full | Bortezomib‐Encapsulated Dual Responsive Copolymeric Nanoparticles for Gallbladder Cancer Targeted Therapy |
title_fullStr | Bortezomib‐Encapsulated Dual Responsive Copolymeric Nanoparticles for Gallbladder Cancer Targeted Therapy |
title_full_unstemmed | Bortezomib‐Encapsulated Dual Responsive Copolymeric Nanoparticles for Gallbladder Cancer Targeted Therapy |
title_short | Bortezomib‐Encapsulated Dual Responsive Copolymeric Nanoparticles for Gallbladder Cancer Targeted Therapy |
title_sort | bortezomib‐encapsulated dual responsive copolymeric nanoparticles for gallbladder cancer targeted therapy |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895115/ https://www.ncbi.nlm.nih.gov/pubmed/35068071 http://dx.doi.org/10.1002/advs.202103895 |
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