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Inflammation‐Triggered Supramolecular Nanoplatform for Local Dynamic Dependent Imaging‐Guided Therapy of Rheumatoid Arthritis

The aging of population has resulted in a significant increase in the prevalence of rheumatoid arthritis (RA), which is a persistent and recurrent synovial inflammation caused by abnormal immune activation. Herein, the authors designed an inflammation‐triggered disassembly (ITD) nanoplatform by a su...

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Autores principales: Li, Luoyuan, Wang, Xuelong, Gao, Rongyao, Zhang, Bei, Liu, Yuxin, Zhou, Jing, Fu, Limin, Wang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895155/
https://www.ncbi.nlm.nih.gov/pubmed/35023331
http://dx.doi.org/10.1002/advs.202105188
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author Li, Luoyuan
Wang, Xuelong
Gao, Rongyao
Zhang, Bei
Liu, Yuxin
Zhou, Jing
Fu, Limin
Wang, Jian
author_facet Li, Luoyuan
Wang, Xuelong
Gao, Rongyao
Zhang, Bei
Liu, Yuxin
Zhou, Jing
Fu, Limin
Wang, Jian
author_sort Li, Luoyuan
collection PubMed
description The aging of population has resulted in a significant increase in the prevalence of rheumatoid arthritis (RA), which is a persistent and recurrent synovial inflammation caused by abnormal immune activation. Herein, the authors designed an inflammation‐triggered disassembly (ITD) nanoplatform by a supramolecular assembly method, which controls the decomposition and drug release through changes in cytokine concentrations and redox potentials during the onset of arthritis, and its dual‐targeted synergistic effect on collagen‐induced arthritis (CIA) rats resulted in higher cell death rate and immunosuppressive rate. Meanwhile, they propose the local dynamic dependent imaging (LDDI) technology to diagnose the disease status, which may produce corresponding changes with the fluctuation of inflammatory activity and improve the accuracy of dual‐target therapy by monitoring the synovial changes through in situ photoactivation of the second near infrared light (NIR‐II). Very importantly, histological analysis shows that ITD strategy relieved joint destruction and cartilage degeneration and its clinical score is similar to that of the healthy group. Their work provides an effective strategy for the early diagnosis and treatment of acute and chronic inflammation diseases, which can interfere to abnormal immune activation, rather than affecting the normal function of immune system.
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spelling pubmed-88951552022-03-10 Inflammation‐Triggered Supramolecular Nanoplatform for Local Dynamic Dependent Imaging‐Guided Therapy of Rheumatoid Arthritis Li, Luoyuan Wang, Xuelong Gao, Rongyao Zhang, Bei Liu, Yuxin Zhou, Jing Fu, Limin Wang, Jian Adv Sci (Weinh) Research Articles The aging of population has resulted in a significant increase in the prevalence of rheumatoid arthritis (RA), which is a persistent and recurrent synovial inflammation caused by abnormal immune activation. Herein, the authors designed an inflammation‐triggered disassembly (ITD) nanoplatform by a supramolecular assembly method, which controls the decomposition and drug release through changes in cytokine concentrations and redox potentials during the onset of arthritis, and its dual‐targeted synergistic effect on collagen‐induced arthritis (CIA) rats resulted in higher cell death rate and immunosuppressive rate. Meanwhile, they propose the local dynamic dependent imaging (LDDI) technology to diagnose the disease status, which may produce corresponding changes with the fluctuation of inflammatory activity and improve the accuracy of dual‐target therapy by monitoring the synovial changes through in situ photoactivation of the second near infrared light (NIR‐II). Very importantly, histological analysis shows that ITD strategy relieved joint destruction and cartilage degeneration and its clinical score is similar to that of the healthy group. Their work provides an effective strategy for the early diagnosis and treatment of acute and chronic inflammation diseases, which can interfere to abnormal immune activation, rather than affecting the normal function of immune system. John Wiley and Sons Inc. 2022-01-12 /pmc/articles/PMC8895155/ /pubmed/35023331 http://dx.doi.org/10.1002/advs.202105188 Text en © 2022 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Li, Luoyuan
Wang, Xuelong
Gao, Rongyao
Zhang, Bei
Liu, Yuxin
Zhou, Jing
Fu, Limin
Wang, Jian
Inflammation‐Triggered Supramolecular Nanoplatform for Local Dynamic Dependent Imaging‐Guided Therapy of Rheumatoid Arthritis
title Inflammation‐Triggered Supramolecular Nanoplatform for Local Dynamic Dependent Imaging‐Guided Therapy of Rheumatoid Arthritis
title_full Inflammation‐Triggered Supramolecular Nanoplatform for Local Dynamic Dependent Imaging‐Guided Therapy of Rheumatoid Arthritis
title_fullStr Inflammation‐Triggered Supramolecular Nanoplatform for Local Dynamic Dependent Imaging‐Guided Therapy of Rheumatoid Arthritis
title_full_unstemmed Inflammation‐Triggered Supramolecular Nanoplatform for Local Dynamic Dependent Imaging‐Guided Therapy of Rheumatoid Arthritis
title_short Inflammation‐Triggered Supramolecular Nanoplatform for Local Dynamic Dependent Imaging‐Guided Therapy of Rheumatoid Arthritis
title_sort inflammation‐triggered supramolecular nanoplatform for local dynamic dependent imaging‐guided therapy of rheumatoid arthritis
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895155/
https://www.ncbi.nlm.nih.gov/pubmed/35023331
http://dx.doi.org/10.1002/advs.202105188
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