Cargando…
In Vivo Targeting Replication Protein A for Cancer Therapy
Replication protein A (RPA) plays essential roles in DNA replication, repair, recombination, and the DNA damage response (DDR). Retrospective analysis of lung cancer patient data demonstrates high RPA expression as a negative prognostic biomarker for overall survival in smoking-related lung cancers....
Autores principales: | VanderVere-Carozza, Pamela S., Gavande, Navnath S., Jalal, Shadia I., Pollok, Karen E., Ekinci, Elmira, Heyza, Joshua, Patrick, Steve M., Masters, Andi, Turchi, John J., Pawelczak, Katherine S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895377/ https://www.ncbi.nlm.nih.gov/pubmed/35251993 http://dx.doi.org/10.3389/fonc.2022.826655 |
Ejemplares similares
-
Ku–DNA binding inhibitors modulate the DNA damage response in response to DNA double-strand breaks
por: Mendoza-Munoz, Pamela L, et al.
Publicado: (2023) -
Recent Advances in the Development of Non-PIKKs Targeting Small Molecule Inhibitors of DNA Double-Strand Break Repair
por: Kelm, Jeremy M., et al.
Publicado: (2022) -
OB-Folds and Genome Maintenance: Targeting Protein–DNA Interactions for Cancer Therapy
por: Par, Sui, et al.
Publicado: (2021) -
Discovery and development of novel DNA-PK inhibitors by targeting the unique Ku–DNA interaction
por: Gavande, Navnath S, et al.
Publicado: (2020) -
Synthesis and Biological Evaluation of Cardiac Glycosides for Cancer Therapy by Targeting the DNA Damage Response
por: Ainembabazi, Diana, et al.
Publicado: (2022)