Histone H2B Deacylation Selectivity: Exploring Chromatin’s Dark Matter with an Engineered Sortase

[Image: see text] We describe a new method to produce histone H2B by semisynthesis with an engineered sortase transpeptidase. N-Terminal tail site-specifically modified acetylated, lactylated, and β-hydroxybutyrylated histone H2Bs were incorporated into nucleosomes and investigated as substrates of...

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Detalles Bibliográficos
Autores principales: Wang, Zhipeng A., Whedon, Samuel D., Wu, Mingxuan, Wang, Siyu, Brown, Edward A., Anmangandla, Ananya, Regan, Liam, Lee, Kwangwoon, Du, Jianfeng, Hong, Jun Young, Fairall, Louise, Kay, Taylor, Lin, Hening, Zhao, Yingming, Schwabe, John W. R., Cole, Philip A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895396/
https://www.ncbi.nlm.nih.gov/pubmed/35175758
http://dx.doi.org/10.1021/jacs.1c13555

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